检验医学与临床2016，Vol.13Issue(15)：2109-2110,2113,3.DOI:10.3969/j.issn.1672-9455.2016.15.014
消银汤对银屑病小鼠模型血清中IF N-γ和IL-4的影响
Effect of Xiaoyin Decoction on serum IFN-γ and IL-4 in psoriasis mouse model
摘要
Abstract
Objective To observe the effect of Xiaoyin Decoction in treating psoriasis mouse model and to investigate its possible mechanism .Methods The mouse vaginal epithelial model was established .The model mice were divided into the high ,middle and low doses of Xiaoyin Decoction groups ,methotrexate(MTX) group and normal saline group .The effects of Xiaoyin Decoction on the vaginal epithelial cell mitosis were evaluated and the levels of serum IFN‐γ and IL‐4 were detected by ELISA .Results Compared with the control group ,high ,middle and low doses of Xiaoyin Decoction groups could remarkable inhibit the mouse vaginal epithelial cell mitosis and decreased the IFN‐γlevel ,the differences were statistically significant (P<0 .05) ,the high dose group could signifi‐cantly increase the IL‐4 level ,the difference was statistically significant (P<0 .01) .Conclusion Xiaoyin Decoction has the effect for inhibiting epidermal cell proliferation ,which plays the curative effect possibly by decreasing the serum IFN‐γlevel and increas‐ing the serum IL‐4 level .关键词
银屑病/消银汤/干扰素-γ/白细胞介素-4Key words
psoriasis/Xiaoyin Decoction/interferon-γ/interleukin-4引用本文复制引用
宋红霞,薛晓东..消银汤对银屑病小鼠模型血清中IF N-γ和IL-4的影响[J].检验医学与临床,2016,13(15):2109-2110,2113,3.基金项目
重庆市万州区科技计划项目（No ．201303042）。 （）
