检验医学与临床2016，Vol.13Issue(15)：2111-2113,3.DOI:10.3969/j.issn.1672-9455.2016.15.015
SCH患者 TSH 水平变化与动脉粥样硬化相关因子的关系研究
Relationship between TSH level change and atherosclerosis related factors in patients with SCH
摘要
Abstract
Objective To investigate the relation between the change of serum thyroid stimulating hormone(TSH) level and ath‐erosclerosis related factors in the patients with subclinical hypothyroidism (SCH) .Methods Totally 100 cases of SCH in our hos‐pital were selected as the research subjects and divided into the mild SCH group (TSH :5 .5 -10 .0 mU/L ,58 cases) and severe SCH group (TSH>10 .0 mU/L ,42 cases) ,40 individuals undergoing the physical examination in the outpatient department were selected as the control group .TSH ,carotid intima‐media thickness (CIMT) and other indicators were detected and the detection re‐sults were compared among 3 groups .Results The detection values of MAP ,TG ,FT3 ,FT4 ,TNF‐αmeasured values had no statis‐tically significant differences among 3 groups (P>0 .05);the detection values of TC ,LDL‐C ,CRP and CIM T in the mild and severe SCH groups were significantly higher than those in the control group (P<0 .05) ,while the HDL‐C detection value was significant‐ly lower than that in the control group ,and the differences were statistically significant (P<0 .05);the detection values of LDL‐C , CRP and CIMT in the severe SCH group were significantly higher than those in the mild SCH group ,and the difference was statis‐tically significant (P<0 .05);serum TSH level in SCH patients was positively correlated with TC ,LDL‐C and CIMT (P<0 .05) , and negatively correlated with the HDL‐C level (P<0 .05) .Conclusion The patients with SCH show abnormal lipid metabolism and inflammation ,and these factors may lead to the occurrence and development of atherosclerosis .关键词
亚临床甲状腺功能减退/促甲状腺激素/动脉粥样硬化Key words
subclinical hypothyroidism/thyroid stimulating hormone/atherosclerosis引用本文复制引用
张丽,罗荔,王晨菲,张春雪,陆春晖,李晓岚..SCH患者 TSH 水平变化与动脉粥样硬化相关因子的关系研究[J].检验医学与临床,2016,13(15):2111-2113,3.基金项目
新疆维吾尔自治区自然科学基金面上项目（2015211C175）。 （）
