摘要
Abstract
Objective To investigate the influence of dexmedetomidine on postoperative cognitive function in elder patients with thoracic surgery under intravenous anesthesia .Methods Eighty ASA Ⅰ - Ⅲ elderly patients with thoracic surgery under intrave‐nous anesthesia were selected and randomly divided into dexmedetomidine group (D) and control group(C) ,40 cases in each group . The group D was slowly given intravenous dexmedetomidine 1 μg/kg at 15 min before anesthesia and maintained by dexmedetomi‐dine 0 .5 μg/(kg・h) .The group C was given the equal volume of normal saline by pump infusion .The mini‐mental state examina‐tion(MMSE) score was recorded on preoperative 1 d ,postoperative 3 ,7 d .The venous serum concentration of TNF‐αand IL‐6were detected before surgery(T0) ,at the end of surgery(T1) ,on postoperative 3 ,7 d .Results The preoperative MMSE score had no statistical difference between the two groups(P>0 .05) ,but the MMSE score on postoperative 3 d in the group D was significantly higher than that in the control group ,and the difference was statistically significant(P<0 .05) ,which on postoperative 7 d in the two groups recovered to normal .The serum TNF‐α and IL‐6 concentration at T0 had no statistical difference between the two groups(P>0 .05) ,which at T1 ,T2 in the group C was significantly increased compared with that at T0 ,the difference was statisti‐cally significant(P<0 .05) ,the IL‐6 concentration at T1 in the group D was decreased compared with that at T0 ,the difference was statistically significant (P<0 .05);the concentration of TNF‐α,IL‐6 at T1 ,T2 in the group D were significantly lower than those in the group C ,the difference was statistically significant(P<0 .05) .Conclusion Dexmedetomidine can decrease the serum TNF‐αand IL‐6 levels and the occurrence of postoperative cognitive disorder in the elderly patients with thoracic surgery under intravenous an‐esthesia .关键词
右美托咪定/老年患者/术后认知功能Key words
dexmedetomidine/elder patients/postoperative cognitive dysfunction
