检验医学与临床2016，Vol.13Issue(15)：2144-2145,2148,3.DOI:10.3969/j.issn.1672-9455.2016.15.027
右美托咪定对骨科下肢手术患者止血带诱发炎症的影响及机制研究
Study on influence and mechanism of dexmedetomidine on tourniquet-induced inflammation in patients undergoing lower limb surgery
陈愉 1万锐杰 1郭波 2卢卫忠 1冉金伟 1杨婧3
作者信息
- 1. 重庆市中医院骨科 400021
- 2. 重庆市中医院麻醉科 400021
- 3. 重庆市中医院妇产科 400021
- 折叠
摘要
Abstract
Objective To investigate the influence of dexmedetomidine on tourniquet‐induced inflammation in the patients with lower limb surgery .Methods Forty‐eight patients needing lower limb surgery in the orthopedic department of our hospital from June 2013 to March 2015 were divided into the dexmedetomidine group and control group according to the random number table ,24 cases in each group .All cases adopted the subarachnoid block combined with epidural anesthesia .The dexmedetomidine group was given the loading dose of dexmedetomidine 1μg/kg after puncture and maintenance dose of dexmedetomidine 0 .5μg/(kg・h) .The control group was given the same volume of normal saline .The serum levels of TNF‐α,IL‐6 ,ICAM‐1 and NF‐κB were measured by enzyme‐linked immunosorbent assay(ELISA) before using tourniquet(T1) ,at the time of tourniquet release(T2) and 30 min after tourniquet release(T3) .Results The incidence rate of bradycardia in the dexmedetomidine group was significantly higher than that in the control group(P<0 .05);the levels of serum inflammatory factors at T0 showed no statistically significant difference between two groups (P>0 .05) .The levels of serum inflammatory factors at T1 ,T2 in the two groups were significantly higher than those at T0 ,the difference was statistically significant(P<0 .05) .The levels of TNF‐α,IL‐6 ,ICAM‐1 and NF‐κB at T1 ,T2 in the dexme‐detomidine group were significantly lower than those in the control group ,the differences were statistically significant(P<0 .05) . Conclusion Dexmedetomidine might alleviate the tourniquet‐induced inflammation reaction process in the patients with lower limb surgery via down‐regulating serum NF‐κB level .关键词
右美托咪定/下肢手术/止血带/炎症Key words
dexmedetomidine/lower limb surgery/tourniquet/inflammation引用本文复制引用
陈愉,万锐杰,郭波,卢卫忠,冉金伟,杨婧..右美托咪定对骨科下肢手术患者止血带诱发炎症的影响及机制研究[J].检验医学与临床,2016,13(15):2144-2145,2148,3.
