检验医学与临床2016，Vol.13Issue(z1)：75-77,3.DOI:10.3969/j.issn.1672-9455.2016.25.030
血清抗环瓜氨酸肽抗体类风湿因子检测对类风湿关节炎的早期诊断价值研究
The value of serum anti-CCP antibody and rheumatoid factors in rheumatoid arthritis early diagnosis
摘要
Abstract
Objective To explore the value of serum anti‐cyclin citrullinated peptide(anti‐CCP)antibody and rheumatoid factore (RF)in rheumatoid arthritis early diagnosis .Methods Using enzyme‐linked immunosorbent assay(ELISA)and immunity transmis‐sion turbidimetry(ITA)methods to detect the anti‐CCP antibody and RF serum level in 86 cases RA patients(RA group)and 62 case non‐RA autoimmune disease patients(non‐RA group) ,then analyzed the diagnosis value of these two factors .Results The positive rates of anti‐CCP antibody ,RF and combined detection in RA group were significantly higher than non‐RA group ,meanwhile ,the rate of combined detection was higher than the others in RA group (P<0 .05);The specificity and positive values of anti‐CCP anti‐body were obviously higher than RF(P<0 .05);The sensitivity and negative value of combined detection were better than anti‐CCP antibody and RF(P<0 .05) .Conclusion Both anti‐CCP antibody and RF are the important creterias in rheumatoid dignosis ,com‐bined these two factors can significantly improve the accuracy of RA clinical diagnosis and contribute to distinguish from orher con‐nective tissue disease .关键词
抗环瓜氨酸肽抗体/类风湿因子/类风湿关节炎/诊断价值Key words
anti-CCP antibody/Rheumatoid factor/Rheumatoid arthritis/Diagnosis value引用本文复制引用
陈新春..血清抗环瓜氨酸肽抗体类风湿因子检测对类风湿关节炎的早期诊断价值研究[J].检验医学与临床,2016,13(z1):75-77,3.
