农药学学报2016，Vol.18Issue(4)：407-415,9.DOI:10.16801/j.issn.1008-7303.2016.0057
有机磷类杀虫剂对非靶标水生动物的毒性机制研究进展
Review on toxic mechanisms of organophosphate insecticides towards non-target aquatilia
摘要
Abstract
Organophosphate insecticides (OPs) in aquatic environmental contaminants have become a threat toward non-targeted aquatilia species. OPs compounds bear a general core structure, exerting their toxic effects primarilyvia the inhibition of acetylcholinesterase (AChE). However, only this canonical mechanism (cholinesterase-based) cannot explain the wide-variety of adverse consequences caused by the OPs exposure. The inhibition of cholinesterase enzymes plays a key role in the toxicology of OPs, which is associated with neurobehavioral abnormal. Furthermore, as endocrine disruptors, OPs not only induced changes in endocrine systems, but also caused changes in the reproductive system and sex differentiation. Oxidative stress induced by the OPs exposure could lead to genotoxic effects and subsequent damage to DNA formation and immunological responses, which would result in the outbreak of different toxic manifestations. This paper reviews the literature on the toxic mechanisms of OPs towards non-target aquatilia organisms that might affect such fundamental processes (development, growth and population) and includes neurobehavioral effects, endocrine-disrupting actions, reproductive system and sex differentiation changes, oxidative stress, DNA damage, genotoxic effects and immunological responses. The research fields of these OPs that warrant further attentions were also discussed.关键词
有机磷类杀虫剂/水生动物/毒性机制/靶标/研究进展Key words
organophosphate insecticides/aquatic/toxic mechanisms/target/review分类
资源环境引用本文复制引用
李勃,马瑜,张育辉..有机磷类杀虫剂对非靶标水生动物的毒性机制研究进展[J].农药学学报,2016,18(4):407-415,9.基金项目
陕西省科学技术研究发展计划项目(2014K02-10-01；2015NY038) （2014K02-10-01；2015NY038）
