农药学学报2016，Vol.18Issue(4)：424-430,7.DOI:10.16801/j.issn.1008-7303.2016.0059
啶酰菌胺类似物的合成及抑菌活性
Synthesis and antifungal activity of novel analogs of boscalid
摘要
Abstract
A series of novel 2-chloro-nicotinamides (3a-3h,5a-5n) were designed and synthesized based on the lead compound boscalid. The structures were characterized by1H NMR,13C NMR and HRMS. The preliminary results showed that most of the compounds possessed some fungicidal activity to seven phytopathogenic fungi at 50 μg/mL. Notably, compound3h showed similar fungicidal activity and the broadest spectrum as boscalid. It exhibited the inhibition rate of 94.1% and 95.6% to the Colletotrichum orbiculare andBotrytis cinerea, respectively and the EC50 value againstRhizoctonia solani,C. orbiculare andPhytophthora infestans was 4.56,14.35 and 58.86 μg/mL, respectively.关键词
啶酰菌胺/酰胺/抑菌活性/琥珀酸脱氢酶抑制剂Key words
boscalid/amide/fungicidal activity/succinate dehydrogenase inhibitors分类
化学化工引用本文复制引用
杜士杰,覃兆海..啶酰菌胺类似物的合成及抑菌活性[J].农药学学报,2016,18(4):424-430,7.基金项目
“十二五”国家科技支撑计划资助项目(2015BAK45B01)；铜仁学院博士基金启动项目(trxyDH1509) （2015BAK45B01）
