农药学学报2016，Vol.18Issue(4)：431-438,8.DOI:10.16801/j.issn.1008-7303.2016.0060
氯菊酯异构体对人类绒毛膜癌 JEG-3细胞内分泌的选择性干扰
Endocrine disruption effect of permethrin isomers to the chorion carcinoma JEG-3 cells
摘要
Abstract
The endocrine disruption effect of four permethrin isomers to the chorion carcinoma JEG-3 cells was investigated. JEG-3 cell lines was employed as thein vitro model and the potential risks of these compounds to maternal-fetal health were also evaluated. Four permethrin isomers were separated by HPLC. The results of real-time reverse transcription polymerase chain reaction (RT-PCR) revealed that those four isomers, in RNA levels, exhibited selective influence on the relative expression amounts of the genes correspounding to gonadotropin-releasing hormone (GnRH) and its receptor, the enzymes of the steroidogenesis pathway and human leucocyte antigen G (HLA-G). The endocrine disruption effects induced by 1R-cis-PM and 1S-trans-PM were more significant than that induced by 1S-cis-PM and 1R-trans-PM.关键词
氯菊酯/异构体/人类绒毛膜癌细胞/内分泌干扰Key words
permethrin/isomer/JEG-3 cells/endocrine disruption分类
农业科技引用本文复制引用
钮利喜,王萍,朱欣凯,陆颖冲,赵美蓉..氯菊酯异构体对人类绒毛膜癌 JEG-3细胞内分泌的选择性干扰[J].农药学学报,2016,18(4):431-438,8.基金项目
国家自然科学基金重点项目(21337005) （21337005）
