实用医学杂志2016，Vol.32Issue(13)：2187-2190,4.DOI:10.3969/j.issn.1006-5725.2016.13.032
高分辨率CT肺气肿定量与慢性阻塞性肺疾病严重程度的相关性
Correlations between emphysema quantification and severity of chronic obstructive pulmonary disease
张攀 1于化鹏 1樊慧珍 1吴树瀚 1刘洁露 1方泽葵 1阎超群2
作者信息
- 1. 510280 广州市，南方医科大学珠江医院呼吸科
- 2. 510280 广州市，南方医科大学珠江医院放射科
- 折叠
摘要
Abstract
Objective To analyze the correlation between emphysema extent measured by high resolution computed tomography (HRCT) and pulmonary function tests, symptom score in patients with chronic obstructive pulmonary disease ( COPD ) , and to study the value of HRCT in the emphysema quantification in the clinical evaluation of COPD patients. Methods 78 patients with stable COPD were recruited to take the HRCT scan , and emphysema extent was qualified by measuring the proportion of low attenuation area in the whole lung (LAA%). Correlations between LAA% and indices of pulmonary function test, bronchial dilation test, mMRC scale, CAT score and six minutes walking distance (6MWD) were assessed. Results LAA% was negatively correlated with FEV1/FVC and DLCO%pred, and the correlation coefficients were -0.759 and -0.589 (P <0.01), respectively. LAA% was positively related to mMRC score (r = 0.342, P < 0.01), and negatively asso-ciated with 6MWD (r = -0.365,P< 0.01). There was no association between LAA% and indices of bronchodila-tion test (⊿FVC, ⊿FVC%, ⊿FEV1, ⊿FEV1%) (P > 0.05). Conclusions The severity of emphysema measured by HRCT is well correlated with the clinical symptoms , pulmonary function tests and exercise capacity in COPD patients. It can be used to diagnose emphysema early and to evaluate the severity of the disease com-prehensively. Thus, the risk factors of COPD can be controlled and the prognosis of the patients can be im-proved.关键词
肺疾病,慢性阻塞性/高分辨率CT(HRCT)/肺气肿Key words
Pulmonary disease/Chronic obstructive/High-resolution CT/Emphysema引用本文复制引用
张攀,于化鹏,樊慧珍,吴树瀚,刘洁露,方泽葵,阎超群..高分辨率CT肺气肿定量与慢性阻塞性肺疾病严重程度的相关性[J].实用医学杂志,2016,32(13):2187-2190,4.
