实用医学杂志2016，Vol.32Issue(13)：2227-2230,4.DOI:10.3969/j.issn.1006-5725.2016.13.045
2型糖尿病患者血清中壬基酚负荷的检测及分析
The load of serum nonylphenol in patients with type-Ⅱdiabetes mellitus
摘要
Abstract
Objective To detect the load of serum Nonylphenol (NP) in patients with typeⅡdiabetes mellitus (T2DM), and reveal the correlations of serum NP with blood glucose and lipids. Methods According to the WHO expert committee on diabetes diagnostic criteria in 2013 , 144 T2DM patients at endocrinology department in our city were enrolled from March to October 2014. Meanwhile , 117 healthy examinees were enrolled as the healthy control group, The blood glucose, the levels of NP, and ER were compared. Results Diabetes mellitus group was that of normal group in The blood glucose , the levels of NP and ER of the T2DM patients were significantly higher than those of the healthy control cases (P<0.001). Positive relationships between the level of serum NP and blood glucose, ER and triglycerides were revealed (r=0.357, P<0.001; r=0.424, P<0.001; r=0.206, P<0.001), but serum NP was negatively correlated with high-density lipoprotein cholesterol (r=-0.503, P<0.001). Conclusions The healthy control cases and the T2DM patients have been contaminated by NP , and the T2DM patients have high load of serum NP. NP may directly damage the pancreas, and restrain the regulating function, and it may affect the endocrine regulation by increasing the expression of estrogen receptor to exert a quasi estrogen effect.关键词
糖尿病,2型/壬基酚/血糖/血脂Key words
Diabetes melitus, type 2/Nonylphenol/Fasting plasma glucose/Blood fat引用本文复制引用
罗娅,郑国波,杨雪峰,俞捷,王德婧,杨雪松,杨静,许洁..2型糖尿病患者血清中壬基酚负荷的检测及分析[J].实用医学杂志,2016,32(13):2227-2230,4.基金项目
国家自然科学基金（编号81360439，81560527），贵州省科技厅基金（编号黔科合LH字［2014］7543，［2015］7521号，黔科合 J 字［2014］2177号，［2014］2185号），2015年遵义医学院招标课题（编号2013F-68），贵州省教育厅青年基金（编号黔教合KY字［2013］198），遵义医学院学科建设经费资助，贵州省卫生厅基金 （）
