实用医学杂志2016，Vol.32Issue(14)：2313-2315,3.DOI:10.3969/j.issn.1006-5725.2016.14.018
广西肝癌高发区乙型肝炎病毒基因型分析
Analysis of hepatitis B virus genotype in regions in Guangxi with high incidence of primary liver cancer
摘要
Abstract
Objective To explore the distribution and characteristics of hepatitis B virus (HBV) genotype in the region in Guangxi with high incidence of primary liver cancer (PLC). Methods 103 pairs of samples from the sex- and age-matched members with HBsAg-positive from PLC-clustering families (the experimental group) and carcinoma-free families (control group) were collected. Nested polymerase chain reaction (PCR) and sequencing methods were applied for the analysis of HBV genotype. Results Four HBV genotypes: B, C, B/C and D, were detected, the percentages of them in the two groups were 31.1%, 63.1%, 1.9%, 1.9% and 30.1%, 55.3%, 6.8%, 2.9%, respectively, showed no significant differences (P > 0.05). HBeAg positive rates were significantly different between genotype C and B (P < 0.05), but no significant differences were showed in such factors as gender, age, ethnic group and HBV DNA level in them (P > 0.05). Conclusions The main genotypes were types B and C besides a small number of combined genotypes B/C and D in the regions of Guangxi with a high incidence of PLC. There may be few relationships between HBV genotypes and the high incidence of PLC for familial clustering in Guangxi.关键词
乙型肝炎/病毒/原发性肝癌/基因型/家族聚集Key words
Hepatitis B virus/Primary liver cancer/Genotype/Familial clustering引用本文复制引用
石仁芳,吴继周,万裴琦,吴健林,宁秋悦,庞裕..广西肝癌高发区乙型肝炎病毒基因型分析[J].实用医学杂志,2016,32(14):2313-2315,3.基金项目
国家自然科学基金项目（编号30960170）；广西教育厅重点课题 （）
