实用医学杂志2016，Vol.32Issue(14)：2329-2332,4.DOI:10.3969/j.issn.1006-5725.2016.14.023
老年抑郁症患者下丘脑－垂体－肾上腺轴功能和垂体、肾上腺体积的变化
Study the HPA axis function, volume of the adrenal and pituitary glands in elderly patients with ;depression
摘要
Abstract
Objective To investigate the changes of hypothalamic-pituitary-adrenal axis (HPA)function, volume of the hypothalamic, pituitary and adrenal glands in elderly patients with depression. Methods Twenty-five cases of elderly patients with depression and 19 healthy elderly patients were enrolled into the patient group and the healthy control group, respectively. Enzyme linked immunosorbent assay was used to measure the level of the main hormone related with HPA axis in blood. The low dose dexamethasone suppression test was used to assessassessment the negative feedback regulation of HPA axis. The volume of the hypothalamus, pituitary and adrenal glands were determined by the magnetic resonance imaging. Results The Beck Depression Scale (BDI-II) and Montgomerie Rating Scale (MADRs) score of the elderly depression patients were significantly higher than those in the healthy control group (P < 0.01). The values of main hormone related with HPA axis in the patient group, such as CRH, ACTH and CORT, were higher than those in the healthy control group (P<0.01). The non- suppression rate of low dose dexamethasone suppression test in the patient group was significantly higher than that in the healthy control group (P < 0.05). The hypothalamus, pituitary and adrenal gland volume of patients group were 4.7%, 18.3% and 17.5% ,respectively. Significant the differences of pituitary and adrenal volume were observed between two groups (P < 0.05). Conclusion The levels of main hormone related with HPA axis in the elderly patients with depression were significantly increased, the non-suppression rate of low dose dexamethasone suppression test was also increased. Meanwhile, the volume of pituitary and adrenal gland in the elderly patients with depression increased.关键词
老年/抑郁症/下丘脑-垂体-肾上腺轴/核磁共振成像/脑垂体体积/肾上腺体积Key words
Elderly/Depression/Hypothalamic-pituitary-adrenal axis/Magnetic resonance imaging/Pituitary volume/Adrenal volume引用本文复制引用
李卓,张海三,李杰,王建洲..老年抑郁症患者下丘脑－垂体－肾上腺轴功能和垂体、肾上腺体积的变化[J].实用医学杂志,2016,32(14):2329-2332,4.基金项目
河南省教育厅科学技术研究重点项目 （）
