实用医学杂志2016，Vol.32Issue(14)：2347-2350,4.DOI:10.3969/j.issn.1006-5725.2016.14.028
HBV前C／C基因启动子区变异与HBeAg阴性CHB患者肝组织病理变化的关系
Analysis on relationship between HBV precore/core promoter region and the liver histological changes in ;HBeAg negative CHB patients
摘要
Abstract
Objective To investigate the relationship between HBV mutations in the precore (PC)/core promoter region and the liver histological changes in HBeAg negative CHB patients. Method A total of 71 HBeAg negative CHB patients with liver biopsy from April 2012 to Dec 2013 were enrolled. DNA was extracted from blood serum, then the HBV S gene and PC/core promoter region were amplified by semi-nested PCR and sequenced. The relationship between significant liver histological changes and viral factors were analyzed by Logistic regression analysis. Results The incidence of significant necroinflammation (15.8% vs. 27.3%, χ2 =1.398, P = 0.237) and significant fibrosis (71.1% vs. 84.4%, χ2= 1.926, P = 0.165) were found to be similar between patients infected with HBV genotype B and genotype C . By Logistic regression analysis including risk factors of age, sex, HBV genotype and mutations (T1753V,A1762T/G1764A,A1846T and G1896A), the A1762T/G1764A mutation in HBV associated with significant necroinflammation (OR = 4.296, P = 0.037), while factors of age, sex, genotype and other mutation were not associated with significant liver histological changes. (all P > 0.05). Conclusion Mutation in PC/core promoter region of HBV may act as a marker to evaluate the liver histological changes.关键词
HBV/前C/C基因区/变异/肝纤维化Key words
HBV/PC/core promoter region/Mutation/Liver fibrosis引用本文复制引用
廖宝林,林思炜,陈伟烈,刘惠媛,陈铿,刘丽儿,施海燕..HBV前C／C基因启动子区变异与HBeAg阴性CHB患者肝组织病理变化的关系[J].实用医学杂志,2016,32(14):2347-2350,4.基金项目
广州市医药卫生科技项目 （）
