实用医学杂志2016，Vol.32Issue(14)：2396-2398,3.DOI:10.3969/j.issn.1006-5725.2016.14.044
乌司他丁对肺外源ARDS患者肺毛细血管通透性及呼吸功能的影响
Effects of Ulinastatin on pulmonary vascular endothelium permeability and respiratory function in ;patients with extrapulmonary acute respiratory distress syndrome
摘要
Abstract
Objective To observe the effects of Ulinastatin on pulmonary vascular endothelium permeability and respiratory function in patients with extrapulmonary acute respiratory distress syndrome(ARDS exp). Methods The data of 39 patients with ARDS exp were retrospectively analyzed.According to whether treated with Ulinastatin or not, all patients were divided into Ulinastatin group(n = 21)and control group(n = 18); The level of extravascular lung water index (EVLWI), pulmonary vascular permeability index(PVPI) and respiratory function were measured before and after the treatment. Results The mortality rate of Ulinastatin group was lower than that of control group (28.6% vs 38.9%). The time of decreasing EVLWI, PVPI and improving PaO2/FiO and respiratory function in Ulinastatin group was shorter than that of control group, and the effect was superior. Conclusion Ulinastatin could reduce EVLWI and PVPI, improve pulmonary compliance and oxygenation, and reduce mortality rate in patients with extrapulmonary acute respiratory distress.关键词
乌司他丁/急性呼吸窘迫综合征/肺毛细血管通透性/血管外肺水Key words
Acute respiratory distress syndrome/Ulinastatin/Pulmonary Vascular Endothelium Permeability/Extravaseular lung water引用本文复制引用
温德良,李智博,温艺超,刘卫江,熊旭明..乌司他丁对肺外源ARDS患者肺毛细血管通透性及呼吸功能的影响[J].实用医学杂志,2016,32(14):2396-2398,3.基金项目
广东省医学科研基金（编号B2015007）；广东省科技计划自筹项目 （）
