摘要
Abstract
Objcetive To observe the clinic efficiency and serum brain natriuretic peptide level changes of patients with acute heart failure in treatment with levosimendan and dobutamine.Mtehods 86 cases of patients with acute heart failure were selected, which were treated in Circulatory Department of Internal Medicine ,the General Hospital of Liaoning Province, Fushun City Bureau of Mines, from November 2013 to November 2015, patients were divided into the observation group (43 cases) and control group (43 cases) .The patients of two groups were treated with routine examination and standardized drug treatment.The patients of control group were treated with dobutamine hydrochloride injection.The patients of observation group were treated with levosimendan.Compare the clinic results, adverse reactions, and improvement of LVESV,LVEDV, LVEF, SV, and changes of BNP, inflammatory cytokines of two groups.Results The patients of the observation group got a total effi-ciency of 90.3%, which was significantly better than the 76.7%of the control group ( P <0.05);The degree of improve-ment of SV,LEVF, SV of the observation group were significantly better than those of the control group after the treatment ( P <0.05);In the terms of BNP, IL-6, TNF-α, hs-CRP, the patients of two groups were all significantly decreased than before ( P<0.05), and the patients of the observation group got more significant decline ( P <0.05); There were chest pain, gastrointestinal reactions, cardiac arrhythmia, headache, hypokalemia and other adverse symptoms occurred in patients of all two groups during treatment, but there was no significant difference between the two groups ( P >0.05).Conclusion With treating patients with acute heart failure, levosimendan can get some exact effects, effectively improve the heart function and reduce the levels of natriuretic peptide, the clinical application of which is safe and reliable.关键词
心力衰竭,急性/左西孟旦/多巴酚丁胺/脑钠肽Key words
Heart failure,acute/Levosimendan/Dobutamine/Brain natriuretic peptide, serum
