疑难病杂志2016，Vol.15Issue(8)：838-840,844,4.DOI:10.3969/j.issn.1671-6450.2016.08.016
丙硫氧嘧啶治疗妊娠伴甲状腺功能亢进症对其甲状腺功能及新生儿的影响
Effects of propylthiouracil in treating pregnancy with hyperthyroidism on their thyroid function and newborns
朱永宁 1尹国才 1谢宁 1李华菊 1郭丽珠1
作者信息
- 1. 272129 山东省济宁医学院附属医院产科
- 折叠
摘要
Abstract
Objective To analyze and investigate the effects of propylthiouracil in treating pregnancy with hyperthy-roidism on their thyroid function and newborns.Methods One hundred and eight cases of patients with hyperthyroidism in pregnancy treated in our hospital from June 2010 to August 2015 were selected, and were divided into the observation group (54 cases) and the control group (54 cases) according to their wishes.The patients of control group were treated without anti-thyroid drugs,while the patients of observation group were treated with antithyroid drug propylthiouracil.Thyroid hormone lev-els, newborns and complications of the two groups were observed and compared.Results After appropriate treatment, the levels of TT3,TT4,FT3, FT4 of observation group were all significantly lower than those of control group[(1.9 ±0.2)nmol/L, (148.6 ±22.7)nmol/L, (6.5 ±0.8)pmol/L, (21.4 ±2.6)pmol/L vs.(3.5 ±1.4)nmol/L, (296.3 ±31.9)nmol/L, (23.7 ±1.3)pmol/L, (55.8 ±3.0) pmol/L, P <0.05]; The levels of TSH of observation group were significantly better than those of control group[(2.25 ±0.29)mU/L vs.(0.11 ±0.02)mU/L, P <0.05];The fetal weight and Apgar score of observation group were significantly better than those of control group ( P <0.05); The complications of observation group were significantly less than those of control group ( P <0.05).Conclusion In treating patients with hyperthyroidism in pregnancy, propylthiouracil can significantly improve the thyroid function of patients, improve fetal weight and get fewer com-plications, which indicates that it has an important clinical significance.关键词
妊娠/甲状腺功能亢进/丙硫氧嘧啶/新生儿Key words
Pregnancy/Hyperthyroidism/Propylthiouracil/Newborns引用本文复制引用
朱永宁,尹国才,谢宁,李华菊,郭丽珠..丙硫氧嘧啶治疗妊娠伴甲状腺功能亢进症对其甲状腺功能及新生儿的影响[J].疑难病杂志,2016,15(8):838-840,844,4.
