摘要
Abstract
ObjectiveTo investigate the changes in the expression levels of peripheral blood T helper 9 (Th9) cells and cytokine interleukin-9 (IL-9) in children in the acute stage of Kawasaki disease (KD) and their clinical signiifcance. MethodsA total of 45 children in the acute stage of KD who were treated from April 2014 to July 2015 were enrolled, and the children were followed up in the recovery stage. Another 45 healthy children who underwent physical examination were enrolled as the control group. Flow cytometry was used to measure the percentage of peripheral blood Th9 cells, and ELISA was used to measure the serum level of IL-9.ResultsThe children in the acute stage of KD showed a signiifcantly higher percentage of Th9 cells and a signiifcantly higher serum level of IL-9 compared with those in the recovery stage and the control group (P<0.05). The percentage of Th9 cells and serum level of IL-9 showed no signiifcant differences between the children in the recovery stage and those in the control group (P>0.05). In the acute stage, the percentage of Th9 cells was positively correlated with the levels of IL-9, C-reactive protein (CRP), procalcitonin (PCT), erythrocyte sedimentation rate (ESR), platelet count (PLT), and globulin (r=0.624, 0.324, 0.402, 0.382, 0.467, and 0.386 respectively, allP<0.05), but negatively correlated with serum albumin (r=-0.306,P<0.05). The serum level of IL-9 was positively correlated with the levels of CRP, PCT, ESR, PLT, and globulin (r=0.365, 0.456, 0.403, 0.423, and 0.453 respectively, allP<0.05), but negatively correlated with serum albumin (r=-0.343,P<0.05). ConclusionsThe children in the acute stage of KD show signiifcant increases in the percentage of peripheral Th9 cells and serum cytokine IL-9 level, which return to normal in the recovery stage. In the acute stage of KD, the expression levels of Th9 and IL-9 are closely correlated with laboratory markers.The results suggest that Th9 cells and IL-9 play important roles in the pathogenesis and outcome of KD.关键词
川崎病/辅助性T细胞9/白细胞介素-9/儿童Key words
Kawasaki disease/T helper 9 cell/Interleukin-9/Child
