局解手术学杂志2016，Vol.25Issue(8)：558-561,4.DOI:10.11659/jjssx.11E015167
阿魏酸钠对大鼠心肌缺血再灌注损伤的保护
Effect of sodium ferulate injection on myocardial function in rat model with myocardial ischemia and reperfusion
摘要
Abstract
Objective To explore the effect of sodium ferulate injection on myocardial function in rat model with myocardial ischemia and reperfusion. Methods Selected 60 rats aged 7 ~8 weeks (7. 26 ± 0. 36 weeks averagely) and randomly divided them into the sham group, myocardial reperfusion group, and the sodium ferulate group, with 20 rats in each group. Observed the changes of the cardiac func-tion indexes of the two groups after perfusion. Results Compared with the sham group,the degree of LVESP and ± dp/dmax decreased sig-nificantly (P<0. 05) in the myocardial reperfusion group and the sodium ferulate group. The descending degree of LVESP and ± dp/dmax 2 hours after reperfusion in the reperfusion group was significantly higher than that in the sodium ferulate group (P<0. 05). Compared with the sham group,the LVEDP of the other two groups showed a rising trend,and it was significantly lower 2 hours after reperfusion in the sodium ferulate group compared to the reperfusion group (P<0. 05). Proportion of apoptosis cells increased in the reperfusion group and the sodium ferulate group,and positive expression rate of Fas in the sodium ferulate group was significantly lower than the reperfusion group (P<0. 05). LDH and CK-MB of content in the blood of rats were significant increased,and it was higer in the reperfusion group compared with the sodium ferulate group (P<0. 05). Compared with the sham group,SOD content in the reperfusion group and the sodium ferulate group decreased obviously (P<0. 05). The MDA content increased,but the degree of increase was lower in the sodium ferulate group (P<0. 05). Conclu-sion Sodium ferulate could protect the myocardial function in rat model with myocardial ischemia and reperfusion to a certain degree.关键词
阿魏酸钠/心肌缺血再灌注/心肌功能/损伤/保护Key words
sodium ferulate/myocardial ischemia-reperfusion/myocardial function/damage/protect分类
医药卫生引用本文复制引用
刘辉,杨初蔚,刘宇飞..阿魏酸钠对大鼠心肌缺血再灌注损伤的保护[J].局解手术学杂志,2016,25(8):558-561,4.基金项目
辽宁省优秀人才培育项目(2014023018) （2014023018）
