局解手术学杂志2016，Vol.25Issue(8)：562-565,566,5.DOI:10.11659/jjssx.01E016023
鼻内镜下单鼻孔经鼻蝶垂体瘤切除术的治疗效果
Research on the effect of endoscopic single nostril transsphenoidal pituitary tumor resection
摘要
Abstract
Objective To discussion the effect of endoscopic single nostril transsphenoidal pituitary tumor resection on improving clini-cal symptoms and related quality of life of patients. Methods Selected 114 cases of patients with pituitary tumors in our hospital from August 2013 to August 2015, and randomly divided them into the nasal endoscopic group and the microscopic group according to the random number table,with 57 patients in each group. Patients of the 2 groups were treated with nasal endoscopic and microscopic single nostril transsphenoi-dal pituitary tumor resection respectively. The operation situation,hormone decline,incidence of complications after surgery and SNOT-20 and VAS score of the two groups were compared. Results Operative time of nasal endoscopic group was significantly higher than that in the mi-croscopic group,whlie the blood loss,length of hospital stay in endoscopic group was significantly lower than the microscopic group,and the difference was statistically significant (P<0. 05). The total resection rate of pituitary tumor of the two groups were of no statistically signifi-cance (P>0. 05). One week after operation,cerebrospinal fluid cell count,cerebrospinal fluid protein,adrenocorticotropic hormone,serum chloride,sodium, growth hormone,and prolactin levels of the nasal endoscopic group were lower than the microscopic group (P<0. 05). The complication rate was 14. 9% in the nasal endoscopic group,which was obviously lower than 59. 6% in the microscopic group (P<0. 05). One week after operation,the SNOT-20 scores and VAS scores were increased in both of the two groups,but the microscopic group increased more significantly (P<0. 05). Conclusion Endoscopic single nostril transsphenoidal pituitary tumor resection surgery cost longer operation time,but it lead to less trauma and less postoperative complications,which may delay the decline of patients’ quality of life and promote the improvement of prognosis.关键词
鼻内镜/经鼻中隔-蝶窦入路/垂体瘤切除术/鼻部相关生存质量Key words
nasal endoscopy/nasal septum-transsphenoidal approach/pituitary tumor resection/nasal related quality of life分类
医药卫生引用本文复制引用
周凯,范雁东,吴鹏飞,吉文玉,冯兆海,张庭荣..鼻内镜下单鼻孔经鼻蝶垂体瘤切除术的治疗效果[J].局解手术学杂志,2016,25(8):562-565,566,5.基金项目
国家自然科学基金(81160150) （81160150）
新疆维吾尔自治区自然科学基金(2012YFY20) （2012YFY20）
