局解手术学杂志2016，Vol.25Issue(8)：570-573,4.DOI:10.11659/jjssx.11E015141
右美托咪定对腰麻下老年患者髋关节置换术后认知功能的影响
Influence of dexmedetomidine on postoperative cognitive function in elder patients after hip replacement surgery under spinal anesthesia
摘要
Abstract
Objective To investigate influence of dexmedetomidine on postoperative cognitive function in elder patients after hip re-placement surgery under spinal anesthesia. Methods Forty elderly patients with ASAⅠ~Ⅲ,undergoing hip replacement with spinal anesth-sia,were randomly divided into dexmedetomidine group( group A) and normal saline group( group B) ,with 20 patients in each group. Dexme-detomidine was given with 1 μg/kg after anesthesia and followed with 0. 5 μg·kg-1 ·h-1 in group A. The equal volume of normal saline was infused in group B. Cognitive function was evaluated before anesthesia,3 and 7 days after surgery by mini-mental state examination( MMSE) . The intraoperative concentration of TNF-α,IL-6,MDA were detected at the time of before surgery(T0),end of surgery(T1),3 days after sur-gery(T2),7 days after suegery. Results There was no significant difference in MMSE score before anesthesia between the two groups (P>0. 05). The difference of MMSE score at postoperative 3 days between two groups was statistical significance (P<0. 05). The MMSE score recovered normal in both groups 7 days later. There was no significant difference of TNF-α,IL-6,MDA concentration at T0 between two groups(P>0. 05). Compared with T0,the concentration of TNF-α,IL-6,MDA at T1,T2 in group B increased,the difference was significant. And the concentration of IL-6 at T1 in group A decreased,compared with that at T0,the difference was significant(P<0. 05). The concentra-tion of TNF-α,IL-6 at T1,T2 and MDA at T2 in group A were lower than those in group B,the difference was significant. (P<0. 05). Con-clusion Dexmedetomidine can decreased the concentration of TNF-α,IL-6,MDA,and improve the postoperative cognitive dysfunction of eld-erly patients who finished the hip replacement surgery under spinal anesthesia.关键词
右美托咪定/认知功能障碍/老年/腰麻/髋关节置换Key words
dexmedetomidine/cognitive dysfunction/elder patients/spinal anesthesia/hip replacement分类
医药卫生引用本文复制引用
杨彪,王冬婷,张瑗,包晓航,李洪,杜智勇,黄河,杨天德..右美托咪定对腰麻下老年患者髋关节置换术后认知功能的影响[J].局解手术学杂志,2016,25(8):570-573,4.基金项目
国家自然科学基金(81572978) （81572978）
