摘要
Abstract
Objective:To carry out a retrospective analysis of antiplatelet drug use in patients with acute coronary syndrome (ACS) ,and compare the clinical application effects of clopidogrel and ticagrelor .Methods:Data of 376 consecutive patients with acute coronary syndrome treated from January 2013 to September 2014 were collected and followed up for one year .The patients'basic information and treatment were analyzed .Primary endpoint events ,recurrence risk of myocardial infarction ,stent thrombosis and hemorrhage ,and drug-related breathing difficulties were compared in two groups of patients . The results of efficacy indices of two types of antiplatelet drugs were discussed ,and reasonable suggestions were put forward . Results:The incidence of primary end point events in the clopidogrel group of patients was 4 .15% ,that of the ticagrelor treatment group was 0 .55% ,and the difference was statistically significant (P=0 .022 5<0 .05);The recurrence incidence of myocardial infarction in the clopidogrel group of patients was 5 .70% , which was significant higher than the ticagrelor treatment group ,which was 1 .09% (P= 0 .014 3< 0 .05);The stent thrombosis in patients of the clopidogrel group was 2 .10% ,that of the ticagrelor treatment group was 0 .55% ,and there were no statistically significant differences ;The incidence of bleeding events in patients of the clopidogrel group was 7 .25% ,which was a little higher than that of the ticagrelor treatment group ,which was 7 .10% ,and there were no significant differences between them .The total incidence of adverse events in patients of the clopidogrel group was 8 .29% ,while that of the ticagrelor treatment group was 10 .93% ,and there were no statistically significant differences . From an economic point of view , ticagrelor costs more than clopidogrel . Conclusions:In the clinical treatment of ACS ,the therapeutic effect of aspirin combined with ticagrelor is superior to aspirin combined with clopidogrelh in that the former can reduce the risk of cardiovascular events in patients without increasing serious bleeding ,but the cost is relatively high .关键词
急性冠状动脉综合征/氯吡格雷/替格瑞洛Key words
acute coronary syndrome/clopidogrel/ticagrelor分类
医药卫生
