中国临床医学2016，Vol.23Issue(3)：374-378,5.
MicroRNA在垂体腺瘤中的诊断与治疗研究进展
IsolationThe role of microRNA in the diagnosis and treatment of pituitary adenomas
摘要
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs involved in the expression and regulation after target gene transcription .Through complete or incomplete pairing with corresponding target gene so as to degrade mRNA or interfere with its translation ,they negatively regulate target gene expression .The differential expression of miRNA has been reported to play a role in the pathophysiological process of neoplastic and non-neoplastic diseases .Pituitary adenomas are tumors that occur in the anterior pituitary gland .Recently ,researchers have found that differential expression of miRNA can be shown in different hormone types ,sizes and invasiveness of pituitary adenoma and pituitary carcinoma ,which implicate the possible role of miRNA as diagnosis marker and therapeutic target of pituitary adenoma .This article will summarize the research progress of miRNA in the diagnosis and treatment of pituitary adenomas .关键词
microRNA/垂体腺瘤/诊断/靶基因Key words
microrna/pituitary adenoma/diagnosis/target gene分类
医药卫生引用本文复制引用
WONG Tyh Chai,顾晔,黄玉莹,张晓彪..MicroRNA在垂体腺瘤中的诊断与治疗研究进展[J].中国临床医学,2016,23(3):374-378,5.基金项目
上海市科委引导项目（134119a1202），上海市申康项目横向课题（SHDC12013121）．Supported by Municipal Science and Technology Commission Guidance Project of Shanghai （134119a1202） and Horizontal Project of Shanghai Shen Kang Program （SHDC12013121）． （）
