中国全科医学2016，Vol.19Issue(23)：2780-2783,2784,5.DOI:10.3969/J.issn.1007-9572.2016.23.008
血清S-100β水平和小儿危重病例量表评分预测手足口病并发脑炎患儿预后的价值研究
Values of Serum S-100β Level and Pediatric Critical Illness Scale in Predicting Hand - foot - mouth Disease Children Complicated With Encephalitis
摘要
Abstract
Objective To investigate the value of serum S-100β level and pediatric critical illness scale(PCIS)in prognostic evaluating the hand - foot - mouth disease(HFMD)children complicated with encephalitis. Methods 190 children with HFMD,who received treatment in the Second People′s Hospital of Zunyi from December 2012 to December 2014,were enrolled as the research obJects in this study. Based on whether children were complicated with encephalitis,we divided the children into HFMD complicated with encephalitis group(60 cases)and HFMD general group(130 cases). Other 40 children, who were regarded as healthy after physical examination in the physical examination center of this hospital at the same period, were included as the control group. We collected necessary information of the HFMD children complicated with encephalitis within the 24 - hour after their being admitted into the hospital,and scored their critical illness condition based on PCIS,then divided the children as non - critical illness cases,critical illness cases and extremely critical illness cases. S-100β and WBC were detected by the extracted 3 ml fasting blood,which were got from HFMD children 12 h after their being admitted into the hospital and from the physical examination of control group. Also HFMD children′s death duration of hospital stay was recorded. Results There were significant difference in S-100β level and WBC among the different groups(P < 0. 05);the S-100β level of HFMD complicated with encephalitis group was higher than that of the HFMD general group and the control group,and the WBC of the HFMD general group and the HFMD complicated with encephalitis group was higher than that of the control group, which showed significant differences(P < 0. 05). The fatality rate of the HFMD complicated with encephalitis group was 20%(12 / 60),which was higher than 4. 6% (6 / 130)in the HFMD general group,which showed significant differences( χ2= 18. 32,P < 0. 05 ). There was significant difference in the S-100β level and the fatality rate of the HFMD children complicated with encephalitis among different critical illness degrees(P < 0. 05);the S-100β level and the fatality rate of the critical illness cases were higher than those of the non - critical illness cases,and the S-100β level and the fatality rate of extremely critical illness cases were higher than those of the non - critical illness cases and critical illness cases,which showed significant differences( P < 0. 01 ). The S-100β level of the HFMD children complicated with encephalitis was negatively correlated with the score of PCIS(r = - 0. 478,P < 0. 01). The area under ROC curve of the HFMD children complicated with encephalitis,predicted as death through S-100β level,was 0. 888〔95% CI(0. 834,0. 947),P < 0. 01〕,when the taken critical value was 2. 91 μg/ L,the sensitivity and the specificity were 84. 46% and 82. 50% respectively. The area under ROC curve of the HFMD children complicated with encephalitis,predicted as death through PCIS,was 0. 873〔95% CI(0. 808, 0. 938),P < 0. 01〕,and when the critical value was 69,the sensitivity and the specificity were 83. 10% and 81. 24%respectively. Conclusion The serum S-100β level and PCIS score can reflect the severity degree of the HFMD children complicated with encephalitis,and have high accuracy in predicting the prognosis of the HFMD children complicated with encephalitis.关键词
手足口病/脑炎/S-100β/小儿危重病例量表/预后Key words
Hand - foot - mouth disease/Encephalitis/S-100β/Pediatric critical illness scale/Prognosis分类
医药卫生引用本文复制引用
熊燚,王健,魏笛,冯亚..血清S-100β水平和小儿危重病例量表评分预测手足口病并发脑炎患儿预后的价值研究[J].中国全科医学,2016,19(23):2780-2783,2784,5.基金项目
贵州省卫生厅科学技术基金项目（gzwkJ2013-1-060）；遵义市科学技术基金项目［遵义市科合社字（2013）37号］ （）
