摘要
Abstract
Objective To investigate the clinical efficacy of XuebiJing inJection combined with hemodialysis in treating acute kidney inJury caused by bee sting. Methods We selected 252 patients who suffered acute kidney inJury caused by bee sting. Participants came from the Affiliated Hospital of Clinical Medicine College of Panzhihua University,Central Hospital of Panzhihua and Pangang Group General Hospital of Panzhihua from February 2011 to October 2014. These patients were divided into observation group(n = 132)and control group(n = 120)according to different treatments. The two groups were performed supportive expectant treatment after admission,and patients in observation group recieved introvenous drip of XuebiJing inJection 50 ml and 5% glucose solution 250 ml,2 times per day for 7 days. The two groups were also treated with hemodialysis,and the times of hemodialysis was determined according to the change of disease conditions. On the morning before and the 3rd and 7th day after treatment,we drew patients′ venous blood to measure BUN,Scr,Cys-C and CRP levels. Clinical effect was evaluated by Scr level;duration of oliguria stage and the length of hospital stay were recorded. Results Pretherapy,post - treatment and treatment methods had an interaction effect on the levels of BUN,Scr,Cys-C and CRP(P < 0. 05). There were significant differences between the main effects of levels of BUN,Scr,Cys-C and CRP before and after treatment(P < 0. 05). The main effects of treatment mode on the levels of BUN,Scr,Cys-C and CRP were significantly different(P < 0. 05). The levels of BUN,Scr,Cys-C and CRP in observation group were lower in the 3rd and 7th days after treatment than before(P < 0. 05). After treatment,on the 3rd and 7th day,the observation group had lower levels of BUN,Scr,Cys-C and CRP than control group(P < 0. 05). The total effective rate in observation group was higher than control group,and duration of oliguria stage and the length of hospital stay in observation group were shorter than control group(P < 0. 05). Conclusion XuebiJing inJection combined with hemodialysis can reduce inflammatory state,improve renal function and shorten the length of hospital stay for patients suffer acute kidney inJury caused by bee sting.关键词
急性肾损伤/蜂毒液类/血必净注射液/血液透析/疗效比较研究Key words
Acute kidney inJury/Bee venoms/XuebiJing inJection/Hemodialysis/Comparative effectiveness research分类
医药卫生
