中国全科医学2016，Vol.19Issue(24)：2876-2879,4.DOI:10.3969/j.issn.1007-9572.2016.24.001
糖尿病及他汀类药物治疗对稳定型心绞痛患者循环微小RNA -92a表达的影响研究
Influence of Diabetes and Statin Therapy on Expression of Circulating MicroRNA - 92a in Patients With Stable Angina Pectoris
摘要
Abstract
Objective To investigate the relationship among expression level of circulating microRNA - 92a (miR-92a),diabetes and statin therapy in patients with stable angina pectoris(SAP). Methods 116 SAP patients,who were in the People's Hospital of Guangxi Zhuang Autonomous Region from March 2010 to March 2011,were selected,including 30 patients with diabetes and 46 patients with statin therapy. The circulating miR-92a was detected by RT - qPCR. The difference of the circulating miR-92a expression level in SAP patients with or without combination of diabetic and statin therapy;and the difference of the circulating miR-92a expression level in elderly SAP patients with or without statin therapy were compared. Results The expression level of miR-92a in SAP patients was(0. 53 ± 0. 44). The results of Pearson correlation analysis showed that the age of SAP patients was positively correlated with the expression level of miR-92a( r = 0. 217,P = 0. 019). With the circulating miR - 92 as the dependent variables and age as covariate,covariance analysis showed that diabetes and age had interaction effects on the circulating miR-92a( F = 19. 631,P ﹤ 0. 05);statin therapy and age had interaction effects on the circulating miR-92a(F = 2. 346,P ﹤ 0. 05). The results of multi - factor analysis of variance showed that the expression level of circulating miR-92a in elderly SAP combined with diabetes patients who received statin therapy was lower than that in SAP patients who did not receive statin therapy(F = 22. 084,P = 0. 001);whether receiving statin therapy or not,the circulating miR-92a expression levels of SAP patients combined with diabetes showed no significant differences(F ﹤ 0. 001,P = 0. 992). Conclusion Diabetes and statin therapy have effect on the expression level of circulating miR-92a in SAP patients. Statin therapy can lower the circulating level of miR-92a in SAP patients combined with diabetes,which indicates that statin may improve endothelial function through regulating and controlling miR-92a.关键词
心绞痛,稳定型/老年人/糖尿病/他汀/微 RNAsKey words
Angina,stable/Aged/Diabetes mellitus/Statin/MicroRNAs分类
医药卫生引用本文复制引用
王虹,林英忠,龚国平,马春兰,伍崇信..糖尿病及他汀类药物治疗对稳定型心绞痛患者循环微小RNA -92a表达的影响研究[J].中国全科医学,2016,19(24):2876-2879,4.基金项目
国家自然科学基金资助项目（81360055）；广西卫生厅重点课题（S201315-04）；广西南宁市青秀区科技攻关课题 （）
