摘要
Abstract
Objective To observe the effects of Percutaeous Balloon Mitral Valvuloplasty ( PBMV ) on prethromboticstate of patients with rheumatic mitral stenosis(RMS). Methods 69 patients with RMS from March 2009 to May 2014 in Yishui Central Hospital of Linyi were selected as the observation group,and 27 healthy subjects who had physical examinations in Physical Examination Center of Yishui Central Hospital of Linyi were selected as the control group. All patients had echocardiography 4 weeks before and after PBMV. Mitral valve area( MVA),left atrial diameter( LAD),right atrial diameter(RAD),left ventricular end diastolic dimension(LVEDd),left ventricular end systolic diameter(LVEDs)and right ventricular end diastolic diameter(RVEDs)were recorded. Mean platelet volume(MPV)and the level of P - selectin(PS)of subjects in the control group were measured when they had physical examinations,while those of patients in the observation group were measured before and 4 weeks after PBMV. Results In the observation group,MVA after PBMV was larger than that before PBMV,and LAD and LVEDd were smaller than those before PBMV(P ﹤ 0. 05);there were no significant differences among RAD,LVEDs and RVEDs before and after PBMV(P ﹥ 0. 05). The levels of MPV and PS in the observation group were higher than those in the control group before PBMV(P ﹤ 0. 05);there were no significant differences in the levels of MPV and PS after PBMV between the observation group and the control group( P ﹥ 0. 05);the levels of MPV and PS before PBMV in the observation group were higher than those after PBMV(P ﹤ 0. 05). Before PBMV,MPV were negatively correlated with MVA and positively correlated with PS(P ﹤ 0. 05);before PBMV,MPV had no linear correlation with LAD,RAD,LVEDd,LVEDs and RVEDs(P ﹥ 0. 05). Before PBMV,PS was negatively correlated with MVA( P ﹤ 0. 05);before PBMV,PS had no correlation with LAD,RAD,LVEDd,LVEDs and RVEDs. Conclusion PBMV is an effective measure for RMS. It could improve the clinical symptoms of patients with RMS,and effectively reduce the levels of MPV and PS,which may be beneficial to improve the prethrombosis state.关键词
二尖瓣狭窄/球囊扩张术/血栓形成/平均血小板体积/P 选择素Key words
Mitral valve stenosis/Balloon dilation/Thrombosis/Meam platelet volume/P - selectin分类
医药卫生
