中国全科医学2016，Vol.19Issue(24)：2930-2934,5.DOI:10.3969/j.issn.1007-9572.2016.24.012
骨桥蛋白在子宫内膜异位症中介导细胞迁移与依赖核转录因子κB 通路促进基质金属蛋白酶及尿激酶型纤溶酶原激活物表达中的作用研究
Effects of Osteopontin in Mediating Cell Migration and Promoting the Expression of Matrix Metalloproteinases and Urokinase-type Plasmase Activator Through Nuclear Transcription Factor κB Pathway on Endometriosis
摘要
Abstract
Osteopontin(OPN)is the acid glycoprotein that extracted from the bone cells,and it plays an important role in cell adhesion,invasion,anti - apoptosis and angiogenesis promotion. It presents high expression in gastric cancer,liver cancer,ovarian cancer and thyroid cancer,but weak or low expression in normal human bodies. Endometriosis( EMs)is pathologically a benign disease,but it has biological behaviors that similar to tumor,such as invasion,planting and distant metastasis,moreover it has limited treatment schedules. OPN may mediate the expression of matrix metalloproteinases(MMPs) and urokinase - type plasmase activator(uPA)through nuclear transcription factor κB(NF - κB)pathway,and then induce the occurrence and development of EMs. Therefore,the paper reviews the above process and summarizes its biological characteristics and the role of each factor in EMs pathogenesis,aiming to provide a new idea for targeted drug therapy of EMs.关键词
子宫内膜异位症/骨桥蛋白质/基质金属蛋白酶类/综述文献(主题)Key words
Endometriosis/Osteopontin/Matrix metalloproteinases/Literature review(topic)分类
医药卫生引用本文复制引用
白治苗,姚卫卫,李望舒,卢玉凤,杨眉,哈春芳..骨桥蛋白在子宫内膜异位症中介导细胞迁移与依赖核转录因子κB 通路促进基质金属蛋白酶及尿激酶型纤溶酶原激活物表达中的作用研究[J].中国全科医学,2016,19(24):2930-2934,5.基金项目
国家自然科学基金资助项目 （）
