中国药房2016，Vol.27Issue(22)：3041-3043,3044,4.DOI:10.6039/j.issn.1001-0408.2016.22.06
玉屏风散对肺气虚证模型大鼠免疫功能的影响
Effects of Yupingfeng Powder on Immune Function of Rats with Lung-qi Deficiency Syndrome
摘要
Abstract
OBJECTIVE:To study the effects of Yupingfeng powder on immune function of rats with lung-qi deficiency syn-drome. METHODS:60 SD rats were randomly divided into normal group,model group,positive group [Renshen beiqi tablet 0.6 g (crude drug)/kg] and Yupingfeng powder high-dose,medium-dose and low-dose groups [24,12,6 g (crude drug)/kg],with 10 rats in each group. Except for normal group,those groups were given SO2+comprehensive cold stimulation to induce lung-qi defi-ciency syndrome model. After modeling,treatment groups were given relevant drug solutions intragastrically,and normal group and model group were given constant volume of normal saline intragastrically,once a day,for consecutive 13 d. After administra-tion,serum levels of IL-3 and IL-6,the proportion of CD3+,CD4+,CD8+in T lymphocyte were determined,and pathological chang-es of lung and bronchus were observed. RESULTS:Compared with normal group,serum levels of IL-3 and IL-6 and the propor-tion of CD8+ in T lymphocyte increased significantly in model group,while the proportions of CD3+ and CD4+ in T lymphocyte and the ratio of CD4+/CD8+ decreased(P<0.01);obvious lung and bronchus injury and inflammatory reaction were observed. Compared with model group,serum level of IL-3 decreased significantly in positive group and Yupingfeng powder high-dose group;serum level of IL-6 and the proportion of CD8 + in T lymphocyte decreased significantly in positive group and Yupingfeng powder high-dose and medium-dose groups,while the proportion of CD3+ in T lymphocyte increased significantly;the proportion of CD4+and the ratio of CD4+/CD8+increased significantly in treatment groups(P<0.05 or P<0.01);lung and bronchial injury,and inflam-mation reaction were relieved. CONCLUSIONS:Yupingfeng powder can enhance immune function of rats with lung-qi deficiency syndrome.关键词
玉屏风散/肺气虚证/免疫功能/T淋巴细胞/大鼠Key words
Yupingfeng powder/Lung-qi deficiency/Immune function/T lymphocyte/Rats分类
医药卫生引用本文复制引用
杨胜,张仲林,袁明勇,郑玲利,李燕,廖昌军..玉屏风散对肺气虚证模型大鼠免疫功能的影响[J].中国药房,2016,27(22):3041-3043,3044,4.基金项目
四川省科技厅立项科研课题（No.2012JY0035）；四川省卫生厅立项科研课题 （）
