中国药房2016，Vol.27Issue(22)：3048-3050,3.DOI:10.6039/j.issn.1001-0408.2016.22.08
利托那韦对舒芬太尼在家兔体内药动学的影响
Effects of Ritonavir on the Pharmacokinetics of Sufentanil in Rabbits
摘要
Abstract
OBJECTIVE:To study the effects of ritonavir on the pharmacokinetics of sufentanil in rabbits. METHODS:24 rab-bits were randomly divided into 2 groups,with 12 rabbits in each group. Trial group was given ritonavir 10 mg/kg by gavage and then injected sufentanil 2 µg/kg intravenously after 5 min. Control group was given equal volume of normal saline by gavage and then injected sufentanil 2 µg/kg intravenously. Arterial blood samples 0.3 ml were taken before gavage and 0,0.25,0.5,1,2,3, 4,6,8,10,12,14,24 h after intravenous administration. The plasma concentrations of sufentanil were determined by LC-MS/MS,and DAS 2.0 software was adopted to calculate pharmacokinetic parameters. RESULTS:The pharmacokinetic change of sufen-tanil conformed to two-compartment model in 2 groups. The pharmacokinetic parameters of sufentanil in control group vs. trial group were that t1/2 were(22.0±6.59)and(26.4±1.41)h;MRT0-24 h were(8.6±2.08)and(12.1±3.70)h;AUC0-∞ were(16.1± 5.17)and(38.1±12.95)mg·h/L,respectively. There was statistical significance in MRT0-24 h and AUC0-∞ between 2 groups(P<0.05). CONCLUSIONS:Ritonavir can elevate distribution of sufentanil in rabbits,and prolong retention time of sufentanil.关键词
舒芬太尼/利托那韦/药动学/液相色谱-串联质谱法/药物相互作用/家兔Key words
Sufentanil/Ritonavir/Pharmacokinetics/LC-MS/MS/Drug interactions/Rabbits分类
医药卫生引用本文复制引用
张雪松,张莹,张雪岩..利托那韦对舒芬太尼在家兔体内药动学的影响[J].中国药房,2016,27(22):3048-3050,3.基金项目
上海市卫生局科研课题 （）
