中国药房2016，Vol.27Issue(22)：3051-3053,3.DOI:10.6039/j.issn.1001-0408.2016.22.09
0.03％他克莫司软膏的体外透皮吸收研究
Study on Percutaneous Absorption in vitro of 0.03%Tacrolimus Ointment
摘要
Abstract
OBJECTIVE:To study the percutaneous absorption of 0.03% Tacrolimus ointment,and to compare the difference of domestic test preparation and imported reference preparation. METHODS:Modified Franz diffusion cells were adopted in trans-dermal test in vitro;HPLC-MS method was used to determine permeation amount and rate in vitro,delay time of domestic test preparation and imported reference preparation 0.03%Tacrolimus ointment. RESULTS:24 h in vitro permeation amount of test and reference preparations were(3 907±1 191)and(3 896±1 064)ng/cm2;permeation rates were 186.7 and 182.9 ng/(cm2·h);de-lay time were 1.95 and 2.00 h,respectively(P>0.05). CONCLUSIONS:Test preparation shows good percutaneous property,and is similar to reference preparation in penetration absorbency through nude mice skin.关键词
他克莫司软膏/体外透皮吸收/裸鼠/高效液体色谱-质谱法Key words
Tacrolimus ointment/Percutaneous absorption in vitro/Nude mice/HPLC-MS分类
医药卫生引用本文复制引用
张鹏威,苏文琴,邝少轶,刘玮..0.03％他克莫司软膏的体外透皮吸收研究[J].中国药房,2016,27(22):3051-3053,3.基金项目
海南省应用技术研发与示范推广专项 （）
