中国药房2016，Vol.27Issue(22)：3125-3127,3.DOI:10.6039/j.issn.1001-0408.2016.22.30
左氧氟沙星和曲安奈德双载药眼用凝胶的制备
Preparation of Levofloxacin and Triamcinolone Acetonide Double-loaded Ophthalmic Gel
摘要
Abstract
OBJECTIVE:To prepare Levofloxacin and triamcinolone acetonide double-loaded ophthalmic gel. METHODS:Us-ing levofloxacin hydrochloride and triamcinolone acetonide as main components,carbopol-940P as base material,HPMC K4M as tackifier,Levofloxacin and triamcinolone acetonide double-loaded ophthalmic gel was prepared. Using dissolution time as index, the contents of carbopol-940P and HPMC K4M were determined by single factor test,and dissolution time,viscosity and the con-tents of 2 main components were also determined. RESULTS:The concentrations of carbopol-940P and HPMC K4M were 0.4%and 1.2%,separately. The dissolution time was more than 24 h and viscosity was 1 142.67 Pa·s. The content of levofloxacin hydro-chloride was 97.3% of labelled amount (RSD=0.84%,n=3),and that of triamcinolone acetonide was 92.97% of labelled amount(RSD=1.32%,n=3). CONCLUSIONS:Levofloxacin and triamcinolone acetonide double-loaded ophthalmic gel has been prepared successfully.关键词
左氧氟沙星/曲安奈德/眼用凝胶Key words
Levofloxacin/Triamcinolone acetonide/Ophthalmic gel分类
医药卫生引用本文复制引用
樊莲莲,杨青青,徐翰林,张培雯,苏文成,黄亚,陈宏..左氧氟沙星和曲安奈德双载药眼用凝胶的制备[J].中国药房,2016,27(22):3125-3127,3.基金项目
四川大学德阳校市科技合作专项资金计划项目 （）
