中国药理学通报2016，Vol.32Issue(8)：1041-1043,1044,4.DOI:10.3969/j.issn.1001-1978.2016.08.002
沉默信息调节因子2同源蛋白1（SIRT1）与阿尔茨海默病研究进展
Silent mating-type information regulator 2 homolog 1 (SIRT1) in Alzheimer’ s disease:an update on potential mechanisms
摘要
Abstract
Alzheimer ’ s disease ( AD ) is characterized by pro-gressive loss of memory and other cognitive functions .With re-cent discoveries , activation of silent mating-type information reg-ulator 2 homolog 1 ( SIRT1 ) could attenuate the cognitive dys-function of AD via reducing amyloid-βaggregation and tau pro-tein phosphorylation , inhibiting inflammatory reaction , and regu-lating synaptic plasticity .This review aims to highlight the in-volvement of these new discoveries of SIRT 1, and Akt/protein kinase B(PKB) signaling pathways, for their potential therapeu-tic effect against AD .关键词
阿尔茨海默病/沉默信息调节因子2 同源蛋白1/Akt/蛋白激酶B/β淀粉样蛋白沉积/tau蛋白磷酸化/突触可塑性Key words
Alzheimer’ s disease/silent mating-type information regulator 2 homolog 1/Akt/protein kinase B/amyloid-βaggre-gation/tau protein phosphorylation/synaptic plasticity分类
医药卫生引用本文复制引用
董世芬,张胜威,孙建宁..沉默信息调节因子2同源蛋白1（SIRT1）与阿尔茨海默病研究进展[J].中国药理学通报,2016,32(8):1041-1043,1044,4.基金项目
国家自然科学基金资助项目（ No 81503287）；教育部博士点基金资助项目（ No 20130013120002）；北京优博项目 （）
