中国药理学通报2016，Vol.32Issue(8)：1053-1058,6.DOI:10.3969/j.issn.1001-1978.2016.08.005
FOX家族介导的上皮间质转化在肿瘤转移中的研究进展
Research progress of epithelial mesenchymal transition mediated by FOX family in tumor metastasis
摘要
Abstract
Epithelial mesenchymal transition ( EMT) is one of the important biological processes in tumor invasion and metastasis . However , due to the complexity of EMT signaling pathway and its unclear molecular mechanism , the treatment of EMT is still a worldwide problem .But many studies have proved that EMT is not an irreversible process .In recent years , the research of FOX gene family in EMT shows its important role in tumor metastasis . This review focuses on the FOX-mediated EMT process in many kinds of tumor , aiming to have a better understanding of EMT signaling network , and provide a new target for the effective pre-vention of EMT .关键词
EMT/FOX/转录/分子靶标/肿瘤干细胞/耐药性Key words
EMT/FOX/transcription/molecular target/cancer stem cells/drug resistance分类
医药卫生引用本文复制引用
蒋宗胜,阮君山,王少明..FOX家族介导的上皮间质转化在肿瘤转移中的研究进展[J].中国药理学通报,2016,32(8):1053-1058,6.基金项目
国家自然科学基金面上项目（ No 81273647）；福建省自然科学基金资助项目（No 2013J01365）；福建省卫生系统中青年骨干人才重点项目（ No 2015－ZQN－ZD－2）；国家卫计委共建科学研究基金项目 （）
