中国医学前沿杂志（电子版）2016，Vol.8Issue(7)：69-72,4.
老年H型高血压亚临床炎症变化与颈动脉损害特点的关系和临床意义
Clinical signiifcance and relationship of subclinical inlfammation and carotid artery structure in elderly patients with H-type hypertension
摘要
Abstract
Objective To investigate the relationship and clinical significance of subclinical inflammation and carotid artery structure in elderly patients with H-type hypertension. Method 175 patients with hypertension from June 2013 to August 2015 in our hospital were chosen as the subjects of study, and acccor-ding to the levels of Hcy (≥10μmol/L:H-type hypertension;<10μmol/L:non-H-type hypertension) and ages (≥60 years old:elderly,≥40 years also<60 years old:middle-aged), patients were divided into three groups as follows:elderly patients with H-type hypertension (H1 group, 66 cases), middle-aged grouped in H-type hypertension (H2 group, 48 cases) and elderly with non-H-type hypertension (NH group, 61 cases). The serum subclinical inflammatory markers and carotid artery ultrasound were conducted to analyze the structure and function of carotid artery and the relationship with inflammatory markers in H-type hypertension. Result The difference of age, diastolic blood pressure (DBP) and pulse pressure between H1 group and H2 group were significant (P<0.05), but there were no significant differences in sex ratio, systolic blood pressure (SBP), blood lipid and Hcy levels (P > 0.05). The difference of Hcy level between H1 group and NH group was significant (P<0.01), but there were no significant differences in age, sex ratio, blood pressure and blood lipid levels (P>0.05). The IMT and PS in H1 group were significantly higher than H2 group and NH group (P<0.01, P<0.05), only DC and CCA-mβin H1 group were significantly lower than H2 group (P<0.01), and there was no significantly difference when compared to NH group (P>0.05). The levels of serum IL-6, IL-8, TNF-αin H1 group were significantly higher than H2 group and NH group (P<0.01, P<0.05), and the levels of hs-CRP, CysC in H1 group were significantly higher than H2 group (P<0.05, P<0.01), but not significant when compared to NH group (P>0.05). IMT, PS, IL-6, IL-8, TNF-α, CysC were positively correlated with Hcy level in H1 group (rrespectively = 0.435, 0.316, 0.337, 0.341, 0.281, 0.429, P < 0.01). Conclusion The elderly patients with H-type hypertension are more likely to have carotid artery dysfunction, which closely correlate with the subclinical inflammatory factors, active intervention may prove beneficial.关键词
H型高血压/老年/动脉粥样硬化/炎性标志物Key words
H-type hypertension/Elderly/Atherosclerosis/Inflammatory markers引用本文复制引用
黄芪,刘先铃,徐海,吴强..老年H型高血压亚临床炎症变化与颈动脉损害特点的关系和临床意义[J].中国医学前沿杂志（电子版）,2016,8(7):69-72,4.基金项目
重庆市万州区科学技术项目 （）
