摘要
Abstract
A 71-year-old male patient with diffuse large B cell lymphoma received a chemotherapy by rituxan 375 mg/m2 combined with CHOP (cyclophosphamide 750 mg/m2,pirarubicin 50 mg/m2,vincristine 2 mg,iv,D1, prednisone acetate tablets D1 - D5 , po ) . Eight days after the second cycle of chemotherapy , the patient experi-enced symptoms such as fever , cough and dyspnea , in which empirical use of antimicrobial drug treatment is inef-fective . The disease was diagnosed as interstitial pneumonia by the symptoms combined with relevant laboratory tests and lung imaging features , which was considered to be caused by rituxan . The symptoms were improved sig-nificantly 5 d , while the review of lung CT showed that the inflammation of double lungs were absorbed signifi-cantly 10 d , after withdrawal of the doubtful drugs and treatment with 30 mg prednisone acetate , bid . However , the chest CT showed that the lesions of double lungs disappeared one month after the dose of prednisone acetate was adjusted to 20 mg , qd , while the pulmonary function test result was within the normal range . No interstitial pneumonia was caused after chemotherapy by an improved CHOP protocol in prednisone acetate was at a gradually decreased dosage .关键词
利妥昔单抗/淋巴瘤/间质性肺炎/不良反应Key words
Rituxan/Lymphoma/Interstitial Pneumonia/Adverse Reaction
