浙江医学2016，Vol.38Issue(15)：1238-1240,1249,4.
小鼠人胰腺癌原位移植瘤模型建立及其MicroPET检测研究
Establishment of orthotopic transplatation model of human pancreatic cancer in nude mice
摘要
Abstract
Objective To establish an orthotropic transplatiation mofel of human pancreatic carcinoma in nude mouse. Methods The smal piece of human pancreatic carcinoma from xenograft was implanted subcapsularly in the tail of pancreas in 20 female BALB/c nude mice. The growth of transplanted tumors were observed with microPET imaging 4 weeks after operation, then the animals were sacrificed by cervical dislocation and the samples of tumor were obtained. Results Four weeks after implantation, the orthotopic transplatation nude mice model was established with a success rate of 100.0%. MicroPET showed that the mean uptake value of 18FDG in tumor mass was (4.30±0.35). Conclusion The orthotopic human pancreatic cancer nude mouse model has been successful y established, and MicroPET can be used to examine the growth of transplanted pancreatic carcinoma in nude mice.关键词
胰腺肿瘤/原位移植瘤/裸鼠模型/MicroPETKey words
Pancreatic carcinoma/Orthotopic transplantation tumor/Nude mouse model/MicroPET引用本文复制引用
王兆洪,陈晶晶,黄崇杰,童洪飞,金洲祥,周斌,王继生,陈辉..小鼠人胰腺癌原位移植瘤模型建立及其MicroPET检测研究[J].浙江医学,2016,38(15):1238-1240,1249,4.基金项目
浙江省中医药科技计划项目（2014ZQ020）；温州市公益性科技计划项目 （）
