山东中医杂志2016，Vol.35Issue(8)：673-677,5.
“肺与大肠相表里”理论现代研究启示
Enlightenment of Modern Research on the Theory Lung and Large Intestine form an External-Internal Relationship
摘要
Abstract
The theory that the lung and the large intestine form an external-internal relationship has shown its superiority in long-term treatment based on syndrome differentiation.At present,most of the diseases involving the lung and the large intestine were treated by purgation and dispersing Qi of the lung.The research on the theory is going deeper and the internal relationship between the lung and the large intestine is began to be studied from the microscopic level such as histology,embryology,immunology and neuro-endocrine system,etc.,which gave the interpretation and verification of the possible mechanisms of the relationship between the lung and the large intestine to a certain extent.But seeing from the complexity of mutual relations between Zang and Fu organs established by the meridians,only characterizing the relationship between the lung and the large intestine from one level or the change of one index is not comprehensive.Therefore,based on transcriptomics and bioinformatics,the common differentially expressed genes in the tissue of the lung and the large intestine can be screened from huge amounts of transcription information in disease transmission,the signal pathways which have the same changes of differences can be found and the transmission way in the pathological changes of "lung disease involving the large intestine" and "large intestine disease involving the lung" can be explored.All the above can provide new thoughts and methods for revealing the connotation of the theory.关键词
肺与大肠相表里/肺肠同病/生理机制/病理机制/转录组学Key words
the lung and the large intestine form an external-internal relationship/diseases involving the lung and the large intestine/physiological mechanism/pathological mechanism/transcriptomics分类
医药卫生引用本文复制引用
张纯芳,刘伟志,裴玲燕,柯愈诗,王琳..“肺与大肠相表里”理论现代研究启示[J].山东中医杂志,2016,35(8):673-677,5.基金项目
国家自然科学基金资助项目(编号:81403391) （编号:81403391）
