心理科学进展2016，Vol.24Issue(8)：1217-1227,11.DOI:10.3724/SP.J.1042.2016.01217
干预胆碱M受体对药物成瘾的影响及其与多巴胺的关系
The effect of interference with muscarinic receptor on drug addiction and its relationship with dopamine
摘要
Abstract
Drug addiction is a disease with central nervous system dysfunction.Muscarinic receptor belong to cholinergic system,has five subtypes,M1-M5 receptors.Behavioral research show that interference with M receptor could affect drug addiction behavior.Both opioids and psychoactive drugs could active central DA system.And M receptor regulating dopamine system in various brain areas,implicate there is a potential way that M receptor affect addiction behavior through interaction with DA system.Activing M2 and M4 receptor could inhibit DA system activating,and active M5 receptor could facilitate DA system activating,in corresponding to the effect of intervened with M2、M4、M5 receptor in drug addiction behavioral research.These evidences prove that M receptor regulating DA system in drug addiction behavior,and M receptor could be new neural target for treatment of drug addiction.关键词
药物成瘾/M受体/多巴胺/胆碱能系统Key words
drug addiction/muscarinic receptor/dopamine/cholinergic system分类
社会科学引用本文复制引用
刘昕鹤,田琳,刘佳琳,李新旺..干预胆碱M受体对药物成瘾的影响及其与多巴胺的关系[J].心理科学进展,2016,24(8):1217-1227,11.基金项目
国家自然科学基金项目(31470989). （31470989）
