中华耳科学杂志2016，Vol.14Issue(4)：499-503,5.DOI:10.3969/j.issn.1672-2922.2016.04.014
静脉甘油试验和鼓室钆造影在梅尼埃病诊断中的价值
Diagnostic values of intravenous glycerol test and inner ear imaging with intratympanic gadolinium injection in Meniere’s disease
摘要
Abstract
Objective To study the value of intravenous glycerol test and endolymph space contrast examination by 3D-FLAIR MRI after intratympanic gadolinium injection in the diagnosis of Meniere's disease. Methods Eighty nine cases of Meniere's disease (6 bilateral cases, 95 ears) diagnosed between May 2015 and July 2016 received glycerol fructose test (250 ml, with pure tone tests before and 1, 2 and 3 hour after infusion). Pure tone threshold improvement of 15 dB or more at any 2 frequencies, or 10 dB or more at two adjacent frequencies or at any 3 frequencies or more was considered indicating a positive result. Fifty five patients (including 4 with bilateral Meniere’s disease, total 59 ears) received 3D-FLAIR MRI 24 h after intratympanic gadolinium injection. Results from the two tests were compared. Results Among the 95 ears, glycerol test was positive in 62 ears (65.3%). There was no nausea, vomiting or other adverse reactions. In the 59 ears where results from both tests were available, the rate of positive 3D-FLAIR MRI with gadolinium contrast was 96.6%(57/59), while the rate of positive glycerol test was 67.8% (40/59),(χ2=16.741, P<0.01). Conclusion Both glycerol test and 3D-FLAIR MRI with gadolinium contrast examination showed certain value in the diagnosis of Meniere's disease. Glycerol test is simple, with minimal instrument and technique requirement, and probably suitable for medical centers of all levels. Whereas 3D-FLAIR MRI with gadolinium contrast yields higher positive rate and increased accuracy in diagnosis and for research, but is technology demanding.关键词
梅尼埃病/膜迷路积水/甘油试验/钆造影剂/磁共振成像Key words
Meniere’s disease/Endolymphatic hydrops/Magnetic resonance imaging/Gadolinium DTPA/Glycerol test分类
医药卫生引用本文复制引用
章梦蝶,金占国,徐先荣,张扬,李远军,罗金叶..静脉甘油试验和鼓室钆造影在梅尼埃病诊断中的价值[J].中华耳科学杂志,2016,14(4):499-503,5.基金项目
“十二五”国家科技支撑计划课题(2012BAI12B02）、全军后勤面上项目(CKJ14J013)、全军后勤重点项目(BKJ15J004)、全军后勤标准制定项目(BKJ15B013)Foundation:“Twelfth Five-Year”National Science and Technology Support Program (No:2012BAI12B02), General Program of PLA Logistics Department (No：CKJ14J013), Major Program of PLA Logistics Department (No：BKJ15J004), Standards-setting Program of PLA Logistics Department (No:BKJ15B013) （2012BAI12B02）、全军后勤面上项目(CKJ14J013）
