波谱学杂志2016，Vol.33Issue(3)：406-414,9.DOI:10.11938/cjmr20160305
乙酰甲喹影响猪尿液代谢组的 NMR研究
Effects of Acute Mequindox Exposure on Urinary Metabonome in Pigs
摘要
Abstract
Mequindox is a member of the quinoxaline family, and widely used in Chinese veterinary industry as an antibacterial drug. Toxicity of mequindox and the underlying mechanisms have been studied previously. However, endogenous metabolic alterations in animals caused by mequindox exposure are currently unknown. This study investigated the effects of acute mequindox exposure (10 mg/kg body weight) on urinary metabonome in pigs using an NMR-based metabonomics approach. The results showed that acute mequindox exposure significantly decreased the levels of creatine, hippurate andp-cresol glucuronide in the urine of treated pigs, whereas the levels ofp-cresol and benzoate increased significantly. The changes of urinary metabolic profiles were long-lasting, and did not recover at 144 h post-exposure. At the dose given, mequindox mainly caused disturbance of gut microbial ecosystem. This study provided useful information on the effects of mequindox on metabolism in pigs, and might guide the safe application of mequindox in veterinary industry.关键词
核磁共振(NMR)/肠道菌群/尿液代谢组/乙酰甲喹Key words
NMR/gut microbes/urinary metabonome/mequindox分类
数理科学引用本文复制引用
万钱芬,何庆华,王玉兰..乙酰甲喹影响猪尿液代谢组的 NMR研究[J].波谱学杂志,2016,33(3):406-414,9.基金项目
国家重点基础研究发展计划(“973”计划)资助项目(2009CB118804) （“973”计划）
