波谱学杂志2016，Vol.33Issue(3)：415-421,7.DOI:10.11938/cjmr20160306
复方乙酰水杨酸片中有效成分的DOSY技术分析
Quantitative Analysis of Active Ingredients in Compound Acetylsalicylic Acid Tablets by DOSY
摘要
Abstract
Compound acetylsalicylic acid tablet is a clinical drug having antipyretic, analgesic and anti-inflammatory effects. The present methods to analyze the active ingredients in this drug have many disadvantages. In this study, we used polydimethylsiloxane (PDMS)-assisted diffusion ordered NMR spectroscopy (DOSY), DOSY-correlated spectroscopy (COSY), and relative quantitative1H NMR techniques to analyze the three main active ingredients in this drug. The content ratios among the 3 components could be obtained. It is argued that PDMS-assisted DOSY provides a convenient and efficient method for pharmaceutical quality control of compound acetylsalicylic acid tablets.关键词
复方乙酰水杨酸片/药物评价/核磁共振(NMR)/二维扩散排序谱(DOSY)/二甲基硅油(PDMS)Key words
acetylsalicylic acid/pharmaceutical quality control/NMR/DOSY/polydimethylsiloxane (PDMS)分类
数理科学引用本文复制引用
王丽敏,仇汝臣,黄少华..复方乙酰水杨酸片中有效成分的DOSY技术分析[J].波谱学杂志,2016,33(3):415-421,7.基金项目
国家自然科学基金资助项目(21105108) （21105108）
