波谱学杂志2016，Vol.33Issue(3)：468-478,11.DOI:10.11938/cjmr20160312
核磁共振技术测量生物骨密度的设备及方法
Measuring Bone Mineral Density with NMR
摘要
Abstract
Bone mineral density (BMD) measured by dual energy X-ray absorptiometry is often used as an index for diagnosis of osteoporosis. However, ionization radiation is present in X-rayBMD measurement, and the result can be inaccurate in some caese. In this work, we constructed an NMR equipment that used a Q-switch to achieve echo time as low as 80ms, and thus have the potential to be used forBMD measurement. In theT2 relaxation time spectra of bone measured by this equipment, the peak area at 300~500ms was found to change linearly with theBMD measured by X-ray absorptiometry. Based on this observation, we put forward a method to measurein vitroBMD with NMRT2 relaxation time spectra. This kind of method has advantages such as high measuring speed, no ionization radiation, and high cross-period comparability.关键词
核磁共振/T2弛豫时间谱/双能X射线吸收/超短回波时间/骨密度Key words
NMR/T2 relaxation time spectrum/dual energy X-ray absorptiometry/ultra-short echo time/bone mineral density分类
数理科学引用本文复制引用
李成伟,范东伟,姜佳岐,杜国红,王为民..核磁共振技术测量生物骨密度的设备及方法[J].波谱学杂志,2016,33(3):468-478,11.基金项目
国家重点基础研究发展计划(“973计划”)资助项目(2015CB250902)，国家自然科学基金资助项目(61531002) （“973计划”）
