高等学校化学学报2016，Vol.37Issue(9)：1629-1635,7.DOI:10.7503/cjcu20160292
纳米TiO2催化一锅法合成喹唑啉酮并酞嗪酮及3-酰胺基异吲哚酮并喹唑啉酮类化合物
TiO2 Nanoparticles-catalyzed One-pot Synthesis of Quinazolino[2,1-b] phthalazin-8-one and 3-Acylamino Isoindolo[2,1-a] quinazoline Derivatives
摘要
Abstract
An efficient and simple one-pot method was developed for the synthesis of two kinds of N-fused quinazolinone derivatives using nano TiO2 particles as catalyst from isatoic anhydride, 2-carboxy benzalde-hyde, hydrazides or aromatic hydrazines. Six quinazolino[2,1-b]phthalazin-8-ones and ten 3-acylamino isoin-dolo[2,1-a]quinazolines were obtained in excellent yields, and the reaction refluxed in aqueous ethanol were environmentally friendly. Attractive features of this methodology were its versatility, mild condition and high efficiency in creating two different structures in a single operation.关键词
纳米TiO2/一锅法/喹唑啉酮并酞嗪酮/3-酰胺基异吲哚酮并喹唑啉酮Key words
TiO2 Nanoparticles/One-pot reaction/Quinazolino[2,1-b]phthalazin-8-one/3-Acylamino isoin-dolo[2,1-a]quinazoline分类
化学化工引用本文复制引用
张金,刘佳,马养民,杨秀芳,程佩,范超,卢萍..纳米TiO2催化一锅法合成喹唑啉酮并酞嗪酮及3-酰胺基异吲哚酮并喹唑啉酮类化合物[J].高等学校化学学报,2016,37(9):1629-1635,7.基金项目
陕西省自然科学基础研究计划项目(批准号:2014JQ2064)、陕西省教育厅重点实验室项目(批准号:15JS012)和陕西科技大学博士科研启动基金(批准号:BJ12-26)资助. Supported by the Natural Science Basic Research Plan in Shaanxi Province of China(No.2014JQ2064), the Scientific Research Project Item for Key Laboratory of Shaanxi Province Education Department, China(No.15JS012) and the Foundation for Young Scholars of Shaanxi University of Science & Technology, China(No. BJ12-26) （批准号:2014JQ2064）
