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食管梭形细胞癌286例临床病理特征及生存影响因素分析

姬玲粉付文婷伍玥程让王立东范宗民吴敏杰王苒孔国强孟辉周英发刘太江刘志才

郑州大学学报（医学版）2016，Vol.51Issue(5)：565-567,568,4.

郑州大学学报（医学版）2016，Vol.51Issue(5)：565-567,568,4.DOI:10.13705/j.issn.1671-6825.2016.05.002

食管梭形细胞癌286例临床病理特征及生存影响因素分析

Clinicopathological features and survival impact factors of 286 patients with esophagus spindle cell carcinoma

姬玲粉 ¹付文婷 ¹伍玥 ²程让 ¹王立东 ¹范宗民 ¹吴敏杰 ³王苒 ¹孔国强 ¹孟辉 ⁴周英发 ⁵刘太江 ⁶刘志才⁷

作者信息

1. 郑州大学第一附属医院河南省食管癌重点开放实验室郑州450052
2. 河南省人民医院消化内科郑州450003
3. 新乡医学院基础医学院病理学与病理生理学专业新乡453003
4. 郑州大学第一附属医院病理科郑州450052
5. 郑州大学第二附属医院消化内科郑州450052
6. 获嘉县红十字会医院外科获嘉453800
7. 林州市肿瘤医院胸外科林州456550
折叠

摘要

Abstract

Aim:To characterize the clinicopahological changes and survival impact factors of esophagus spindle cell carcinoma( ESSC) .Methods:All the clinical epidemiological information from 286 ESSC patients was retrospectively ana-lyzed.Results:The detection rate of ESSC in the present database was 0.11%(286/251 707).The sex ratio of male vs. female was 2.11:1.The male median age was 61 years,and the female median age was 62 years.A total of 112 cases were performed pathological biopsy and the accuracy was 50.9%.The most common site for ESSC was in the middle segment of the esophagus(69.1%), followed by the lower segment(18.8%).The most common gross tumor type of ESCC was in-traluminal type(35.5%), followed by fungating type(25.2%), medullary type(12.9%) and ulceration type(12.3%). The local lymph node metastasis rate was 26.3%;only 2.1%of the ESSC patients occurred long distance organ metasta-sis.The early ESSC(T1N0M0) accounted for 31.7%.The five-year survival rate for early and advanced ESSC was 54.5%and 43.7%, respectively.Cox proportional hazards regression model analysis showed that T and M phase were the inde-pendent risk factors for poor prognosis of ESSC[β=0.390,1.588;OR(95%)=1.477(1.181-1.847),4.748(1.666-13.530)].Conclusion: ESSC predominantly occurs in males and in the middle segment of the esophagus,and with a higher misdiagnosis before operation.The intraluminal type is the most common gross tumor type, and the incidence of lymph node metastasis is low.T and M phase are the independent risk factors for poor prognosis of ESSC.

关键词

食管梭形细胞癌/临床流行病学/病理诊断/生存分析

Key words

esophagus spindle cell carcinoma/clinical epidemiology/pathological diagnosis/survival analysis

分类

医药卫生

引用本文复制引用

姬玲粉,付文婷,伍玥,程让,王立东,范宗民,吴敏杰,王苒,孔国强,孟辉,周英发,刘太江,刘志才..食管梭形细胞癌286例临床病理特征及生存影响因素分析[J].郑州大学学报（医学版）,2016,51(5):565-567,568,4.

基金项目

国家自然科学基金委员会和广东省联合重大项目资助 U 1301227；国家科技部863重点专项资助 SQ2015AA 0202183；河南省科技计划项目142300410204 （）

郑州大学学报（医学版）

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ISSN：1671-6825

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