郑州大学学报（医学版）2016，Vol.51Issue(5)：610-613,4.DOI:10.13705/j.issn.1671-6825.2016.05.014
西地那非对西藏小型猪慢性肺动脉高压模型体循环压力的影响
Effects of sildenafil on systemic blood pressure in Tibet minipigs with chronic pulmonary hypertension
摘要
Abstract
Aim:To investigate the effects of sildenafil on the systemic blood pressure of Tibet minipig models with chronic pulmonary hypertension( PH) .Methods:A total of 18 Tibet minipigs were randomly allocated into control group, model group and treatment group, 6 in each group.The Tibet minipigs in model group and treatment group were treated with monocrotaline( MCT) for 42 d to establish PH model.Since day 43, the treatment group was treated with sidenafil (6.0 mg· kg-1 · d-1 ) for 3 weeks.Conventional transthoracic echocardiography was performed at day 42 and day 64.The systemic blood pressure was measured by left carotid artery cannulation linked to a MedLab biological signal collecting and processing system at day 64.Results:At day 64, pulmonary artery pressure and systemic blood pressure of the model group were higher than those of control group(P<0.05);pulmonary artery pressure and systemic blood pressure of the treatment group were lower than those of the model group(P<0.05), and systemic blood pressure was even lower than that of control group(P<0.05).Conclusion:Sildenafil could reduce pulmonary artery pressure, at the same time, also reduce systemic pressure.关键词
西地那非/肺动脉高压/西藏小型猪/体循环血压Key words
sildenafil/pulmonary hypertension/Tibet minipig/systemic blood pressure分类
医药卫生引用本文复制引用
侯梦,刘蓉,廖海星,汪延生,岳敏,张新凤,吴清洪,李洪涛,顾为望..西地那非对西藏小型猪慢性肺动脉高压模型体循环压力的影响[J].郑州大学学报（医学版）,2016,51(5):610-613,4.基金项目
广东省科研基础条件建设项目2012B060300032 （）
