摘要
Abstract
Aim:To research the related factors of severe bone marrow suppression occurred within 3-4 days after the chemotherapy with paclitaxel and nedaplatin( TC program) in patients with gynecologic malignant tumor.Methods:A total of 118 patients with gynecologic malignant tumor were treated with TC chemotherapy,among whom, 58 developed grade 0 toⅠbone marrow suppression( mild group) ,and 60 developed gradeⅡorⅢorⅣbone marrow suppression( severe group) . The relationship between related factors such as age, body mass index, body surface area, internal medicine amalgamative disease, tumor staging, chemotherapy course, tumor type and severe bone marrow suppression after chemotherapy was ana-lyzed by single factor analysis.The influencing factors of severe bone marrow suppression were analyzed by logistic regres-sion analysis.Results:Univariate analysis showed that age, tumor type, tumor stage, chemotherapy course were related to severe bone marrow depression ( P <0.05 ) .Logistic regression analysis showed that cervical cancer, tumor stage, and chemotherapy course were related to severe bone marrow depression(OR=0.046,2.357,3.121,P<0.05).Conclusion:Late stage of tumor, number of chemotherapy course are the risk factors for the occurrence of severe bone marrow suppres-sion;the patients with cervical cancer have lower risk of developing severe bone marrow suppression than those with ovarian cancer.关键词
妇科恶性肿瘤/紫杉醇/奈达铂/化疗/重度骨髓抑制Key words
gynecologic malignant tumor/paclitaxel/nedaplatin/chemotherapy/severe bone marrow suppression分类
医药卫生
