摘要
Abstract
Objective To observe the effect of celecoxib on the analgesic effect of preemptive analgesia in patients after spinal surgery. Methods 180 patients undergoing elective spinal surgery were randomly divided into intravenous PCA group ( P group) and celecoxib preemptive analgesia combined with intravenous PCA group( CP Group) . Patients in the CP group were orally administered celecoxib 1 h before surgery,and all patients were used intravenous self-controlled analgesia pump after operation. The stillness and movement VAS score of 1h,6h,12h,24h,48h after surgery,the Ramsay sedation score,the postoperative anesthesia recovery time,the patient satisfaction and the adverse reaction rate were recorded. Results The 1h,6h,12h stillness VAS scores after surgery in CP group were significantly lower than those in P group;The 1h,6h movement VAS scores after surgery in CP group were significantly lower than those in P group. And there were no significant differences in the sedation score,the postoperative an-esthesia recovery time,the patient satisfaction,and the adding analgesic drug use rate in both two groups of patients after each ob-servation point. Conclusion A single oral dose of celecoxib before operation and preemptive analgesia combined with postopera-tive analgesia can significantly reduce the pain of patients within 24 hours after the spinal surgery,and the analgesic effect is supe-rior,stable and safe,which is recommended for clinical use.关键词
塞来昔布/超前镇痛/脊柱手术/术后镇痛Key words
celecoxib/preemptive analgesia/spinal surgery/postoperative analgesia分类
医药卫生
