陕西医学杂志2016，Vol.45Issue(9)：1114-1117,4.DOI:10.3969/j.issn.1000-7377.2016.09.004
大骨节病软骨中内质网应激性蛋白分子表达变化研究
Changed expression of protein molecule related to ER stress in KBD cartilage
摘要
Abstract
Objective:To investigate the expression of ATF6 and CHOP in KBD cartilage changes and its relationship with KBD cartilage injury .Methods :7 specimens of articular cartilage were collected from KBD patients under operation (KBD group) ,7 cases from patients suffered from osteoarthritis (OA group) as disease control ,6 normal cartilage as normal controls .Expression of AFT6 and CHOP as key regulators in ER stress of three groups articular cartilage was detected using immunohistochemical staining ,significant differences expression among the ar‐ticular cartilage was analyzed .Results :In middle layer ,ATF6‐positive expression rate in KBD group and OA group was significantly higher than this of normal cartilage group ,while in the surface and deep ,ATF6 positive cells a‐mong three groups was no statistical difference.In surface layer ,CHOP‐positive expression rate in OA cartilage was significantly higher than this of KBD and normal ,while no statistical difference was found between KBD and the nor‐mal group;while in middle layer ,CHOP‐positive expression rate in KBD cartilage group and OA group was signif‐icantly higher than normal group ,positive rate of deep in OA cartilage was higher than KBD group.ATF6 of KBD and OA group was mainly expressed in the middle layer ,whilemiddle and deep in normal cartilage ,CHOP of KBD and OA group was mainly expressed in the middle layer .Conclusion :Both ATF6 and CHOP in middle layer of KBD cartilage was increased significantly ,indicating that CHOP may be closely related to the KBD cartilage damage;while ATF6 was related with react Aive cell proliferation after cartilage injury .关键词
骨关节病,原发肥大性/病理生理学/软骨,关节/病理生理学/蛋白/代谢/活化转录因子6Key words
Osteoarthropathy ,primary hypertrophic/physiopathology/Cartilage ,articular/phys-iopathlogy/Egg white/metabolism/AFT6分类
医药卫生引用本文复制引用
易智,武世勋,凌鸣,刘时璋,刘宗智,孙正明,靳占奎..大骨节病软骨中内质网应激性蛋白分子表达变化研究[J].陕西医学杂志,2016,45(9):1114-1117,4.基金项目
陕西省社会发展科技攻关项目 （）
