局解手术学杂志2016，Vol.25Issue(9)：629-631,632,4.DOI:10.11659/jjssx.04E016053
CaSR 在大鼠血管收缩／舒张反应性调节中的作用
Effects of CaSR on vascular relaxation/constriction in rats
摘要
Abstract
Objective To investigate the effects of calcium sensing receptor (CaSR)on vasorelaxation/vasoconstriction of superior mes-enteric artery (SMA)in rats and its relationship to endothelium.Methods With endothelium-intact and endothelium-denuded SMA rings of rats,the effects of CaSR-specific allosteric modulator cinacalcet on the SMA rings pre-contracted with norepinephrine (NE),and vascular contractile response /relaxation reactivity were observed.Results Cinacalcet had no effects on resting tension of SMA rings with or without endothelium.Cinacalcet caused a significant relaxation in the endothelium-intact SMA rings pre-contraction with NE in a dose-dependent manner.Endothelium denudation abolished cinacalcet-induced vasorelaxation.Pretreatment with cinacalcet for 30 minutes decreased the con-tractile response of endothelium-intact SMA rings to NE,but had no significant influence on relaxation reactivity.In the endothelium-denuded SMA rings,cinacalcet did not affect both vasoconstriction and vasorelaxation.Conclusion CaSR plays an important role in the regulation of the vascular reactivity,and this effect is endothelium-dependent.关键词
钙敏感性受体/cinacalcet/内皮/收缩反应性/舒张反应性Key words
calcium sensing receptor/cinacalcet/endothelium/vasoconstriction/vasorelaxation分类
医药卫生引用本文复制引用
彭小勇,李涛,刘良明,杨光明..CaSR 在大鼠血管收缩／舒张反应性调节中的作用[J].局解手术学杂志,2016,25(9):629-631,632,4.基金项目
国家自然科学基金（81571886）；军队医学科技青年培育项目（13QNP118）；教育部留学回国人员科研启动基金 （）
