局解手术学杂志2016，Vol.25Issue(9)：651-653,654,4.DOI:10.11659/jjssx.11E015123
Gankyrin 在胃癌及癌前病变中的表达及意义
Expression of Gankyrin in gastric carcinoma and precancerious lesions and its significance
摘要
Abstract
Objective To evaluate the expression of Gankyrin in gastric carcinoma and preancerious lesions (including chronic atrophic gastritis and gastric epithelial dysplasia)and its clinicopathological significance.Methods Immunohistochemical assay was performed to de-tect the Gankyrin expression in 30 casess of normal gastric mucosa,60 cases of chronic atrophic gastritis,30 cases of gastric epithelial dyspla-sia,and 84 cases of gastric carcinoma.Moreover,the relationship between Gankyrin expression and clinicopathological features of gastric car-cionma was analyzed.Results Gankyrin expression was detected in normal gastric mucosa,chronic atrophic gastritis,gastric epithelial dys-plasia,and gastric carcinoma tissues in varying degrees,and the difference of Gankyrin positive rates was significant in different gastric leions mentioned above (P <0.05).The rate of Gankyrin expression in gastric carcinoma was significantly related with the clinical stage and metas-tasis.There’s no relationship between Gankyrin expression and the age,gender of patients,size,histologic grade of gastric carcinoma.Con-clusion Gankyrin participates in both the carcinogenesis and development of gastric carcinoma.Moreover,Gankyrin is a potential target for the diagnosis,prevention and treatment of gastric carcinoma.关键词
胃癌/癌前病变/Gankyrin/慢性萎缩性胃炎/异型增生Key words
gastric carcinoma/precancerious lesion/Gankyrin/chronic atrophic gastritis/dysplasia分类
医药卫生引用本文复制引用
戴观荣,汤俊华,丁洪亮,赵卫国..Gankyrin 在胃癌及癌前病变中的表达及意义[J].局解手术学杂志,2016,25(9):651-653,654,4.基金项目
广东省自然科学基金 （）
